One-step sustainable extraction of Silymarin compounds of wild Algerian milk thistle (Silybum marianum) seeds using Gas Expanded Liquids.

This work reports the application of Gas Expanded Liquid (GXL) extraction to concentrate the flavonolignan fraction (silymarin) and taxifolin from Silybum marianum seeds, which have proven to be highly valuable health-promoting compounds. GXL using green solvents was used to isolate silymarin with the objective of replacing conventional methods. In one hand, the effect of different compositions of solvents, aqueous ethanol (20%, 50% or 80% (v/v)) at different CO/liquid (25, 50 and 75%) ratios, on the GXL extraction was investigated.

Optimization of Pressurized Liquid Extraction and In Vitro Neuroprotective Evaluation of Untargeted Metabolomics Analysis by UHPLC-MS/MS.

is a spontaneous plant endemic of the North African region. An efficient selective pressurized liquid extraction (PLE) method was optimized to concentrate neuroprotective extracts from fruits. Green solvents were tested, namely ethanol and water, within a range of temperatures between 40 to 180 °C.