Publications by authors named "Noreen Crain"

The purposes of this review are to describe differences between palliative care for adult patients and palliative care for pediatric patients, both generally and in the intensive care unit; to highlight ethical considerations for pediatric intensive care unit patients by using illustrative cases; and to examine the impact of these ethical considerations on decision-making for children and their families.

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Article Synopsis
  • Multisystem inflammatory syndrome in children (MIS-C) is a serious, life-threatening condition linked to COVID-19 that affects multiple organs and shows signs of immune system activation.
  • The exact cause of MIS-C and the severe organ damage it causes are not fully understood, but it has been linked to the human herpesvirus 6 (HHV-6), which can remain dormant in the body and may reactivate during inflammatory responses.
  • A case study revealed a strong correlation between high HHV-6 levels and a specific form of the virus (iciHHV-6) in a MIS-C patient, suggesting that more research is needed to investigate the potential role of iciHHV-6 in the syndrome's development.
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Objective: To evaluate bispectral index technology in critically ill children and compare its performance to standard clinical assessment of sedation level.

Design: Prospective convenience sample.

Setting: Multidisciplinary 16-bed pediatric intensive care unit at a large, urban, university-affiliated children's hospital.

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