[Osteonecrosis of the jaws by using bisphosphonates].

The new generation of bisphosphonates are often used in the treatment of osteoporosis or for certain tumors with bone defects. Between the period of September 2005 and May 2006 we have treated 8 patients at our clinic with a bisphosphonate-induced osteonecrosis in the maxillofacial region. All of these patients went through intravenous bisphosphonate treatment earlier.

Overall survival of oropharyngeal cancer patients treated with different treatment modalities.

Therapeutic modalities of use in tumor therapy can be applied in various combinations to treat malignant lesions of the mesopharynx. A study was made of the overall survival of patients with mesopharyngeal carcinoma treated with different modalities in our institution in the period 1995-2000. In this retrospective study, a total of 66 patients were divided into 4 groups: Patients who took part in 1) intra-arterial chemotherapy and subsequent irradiation; 2) intra-arterial chemotherapy and surgical care; 3) only surgical care; or 4) only irradiation or palliative treatment.

Effect of human organism on the oxide layer formed on titanium osteosynthesis plates: a surface analytical study.

The question of whether or not to remove the titanium osteosynthesis plates used in maxillofacial surgery is not yet answered. These plates can be left a long time in the organism if there is no harmful interaction between the plates and the organism. The authors examined the properties of the surface oxide layers formed on osteosynthesis titanium plates by subsequent thermal and anodic oxidation, together with the properties of plates removed from patients after three years.

[A cross sectional study of titanium plates surface-treated with anodic oxidation].

It is an important modern trend to try to modify the surface properties of titanium implants with titanium oxide produced in various ways. One possibility of surface modification is the formation of an oxide layer by heat and electric treatment. The authors examined three osteosynthesis plates treated with anodic oxidation of Hungarian development.

[Survival prospects of mesopharyngeal carcinoma patients treated primarily with intraarterial chemotherapy. A retrospective study].

Background: The radical removal of mesopharyngeal tumors necessitates very extensive, aggressive surgery. In certain cases, therefore, they strive to ensure the quality of life of these patients by means of two other possibilities in the complex treatment: chemotherapy and irradiation; in this way, over radicality can be avoided.

Aim: One of the elements of the complex therapy may be intraarterial chemotherapy.

[Total upper lip necrosis and loxoscelism caused by violin spider bite].

Arthropods and in particular spiders are a common embodiment of our fears, despite the fact that only a few species are dangerous to man. The authors present a case involving severe local and general reactions to a loxosceles (brown recluse spider) bite. They give an overview of the occurrence of loxosceles spiders, the signs and symptoms of envenomation and the therapeutic possibilities.

Neoadjuvant immunotherapy of oral squamous cell carcinoma modulates intratumoral CD4/CD8 ratio and tumor microenvironment: a multicenter phase II clinical trial.

Purpose: To investigate the clinicopathologic effects of local neoadjuvant Leukocyte Interleukin Injection (LI) regimen in oral squamous cell carcinoma (OSCC) patients. Treatment regimen included LI 800 IU/d as interleukin-2 (IL-2), administered half peritumorally and half perilymphatically five times per week for 3 weeks; low-dose cyclophosphamide; indomethacin; zinc; and multivitamins.

Patients And Methods: Thirty-nine patients diagnosed with T2-3N0-2M0 OSCC participated in the pathology portion of this phase II multicenter study (19 LI-treated patients and 20 historical controls).

[Corrosion study of anodically and thermically surface-treated osteosynthesis plates].

For the fixation of mandibular fractures, at the Department of Oral Surgery and Dentistry at Semmelweis University, anodically and thermically treated TiO2/Ti osteosynthesis plates are used. The corrosion studies were performed in a generally-applied 3-electrode electrochemical measurement cell, with a calomel electrode as reference electrode, and a Pt net as conducting electrode. The cyclic voltammetric measurements demonstrated that the pore-free surface TiO2 layer forms a highly protective barrier on the surface of Ti.

Effect of induction chemotherapy on changes of laminin and syndecan expression in oral squamous cell carcinomas: a prospective, randomized, clinicopathologic and immunohistochemical study.

Sixty patients with tumors of the floor of the mouth or of the tongue (T2N0-1-2M0) were randomized into three treatment groups. The first two groups participated in low-dose inductive chemotherapy, surgery, and then radiotherapy, whereas the third control group underwent only surgery and radiotherapy. In all three groups, studies were made of the stage, grade, sex, localization, extents of expression of the pretreatment laminin and syndecan-1 and the cancer specific survival rate, and the correlations among these.

Histomorphometric and densitometric evaluation of the effects of platelet-rich plasma on the remodeling of beta-tricalcium phosphate in beagle dogs.

Countless possibilities are available in maxillofacial surgery for the filling of bone defects. The best bone substitute known at present is osteogenic autogenous bone, but its use is accompanied by numerous disadvantages. The question has arisen of whether results attained with osteoconductive bone substitutes approach those achieved by the transplantation of autogenous bone.

Surface analysis methods of biomaterials used in oral surgery: literature review.

Titanium is the most frequently used biomaterial in oral surgery because of its positive physical and chemical properties. Clinical studies proved that the properties of titanium can be improved by surface modification techniques. To study the surface of biomaterials, the positive effects of the coatings, the response of the organism (corrosion resistance, physical and chemical stability, the thickness of various coatings, biocompatibility), one must choose and use the adequate analytical method for one's goal.

[Surface analysis of interaction between titan implants treated with anod oxidation and the human organism].

Unlabelled: The examination of interaction between the titan implants treated with anod oxidation and the human organism carried out with surface analytical methods. The favourable properties of metallic titanium have led to its widespread use as an implant material. These properties can be further improved by surface treatment.

[Alveolar bone regeneration stimulated by a combination of platelet-rich plasma and Cerasorb graft in Beagle dogs. Histological and histomorphometric studies].

Healing of extraction wounds was examined in an animal experiment model on Beagle dogs. After bilateral extraction of the premolars of 12 dogs the alveoli were filled up with a combination of beta-tricalcium phosphate (Cerasorb) graft and platelet rich plasma (PRP) on the experimental side, and with Cerasorb alone on the control side. Biopsy specimens were taken from the regenerating bone at 6, 12 and 24 weeks after surgery for histological study.

[Significance of prognostic factors in oral squamous carcinoma].

Despite the considerable advances in the diagnostic and therapeutic possibilities, the prognosis of epithelial tumors in the oral cavity is very poor. A knowledge of the prognostic factors at the beginning of treatment is therefore indispensable for determination of the appropriate therapy for the given patient. These factors may be linked to the patient (e.

[Modern methods for studying the surface of titanium implants (literature review)].

Studies of the coatings found on the surface of titanium implants employed in oral surgery are indispensable for understanding the interactions between the organism and the implant. This paper surveys the theory and practical applicability of the methods most frequently applied to study the surface structure and composition of the material. Detailed accounts are given of various structure investigation methods: scanning electron microscopy, stereo scanning electron microscopy, X-ray diffraction, atomic force microscopy and interference microscopy; and of various composition investigation methods: secondary ion mass spectroscopy, X-ray photoelectron spectroscopy, Auger electron spectroscopy; and also of the corrosion procedures for the study of electrochemical behaviour.

[The effect of platelet-rich plasma on new bone formation by augmentation with osseoconductive bone substitute material in beagle dogs].

Animal experiments were carried out with osseoconductive bone substitute beta-tricalcium phosphate (beta-TCP), with the aim of assessing the effect of the growth factors synthesized by platelets on the speed of beta-TCP incorporation and on the quality of newly formed bone. The question arises whether the results attained with this synthetic material approach are comparable to those attained with autologous bone. Defects in the mandibles of beagle dogs were filled with beta-TCP or with the mixture of beta-TCP and platelet rich plasma (PRP) obtained from autologous blood.

Long-term results with different bone substitutes used for sinus floor elevation.

One of the surgical procedures preceding implantation is elevation of the base of the maxillary sinus. Numerous bone substituting materials (grafts) may be used for this purpose, including autogenous bone, heterografts, xenogenous bone, and synthetic materials alone or in combination or mixed with growth factors and bone morphogenetic protein (BMP) preparations. A study of the frequencies of the failures (graft material resorption or implant loss) after sinus elevations with various graft materials or their combinations was conducted.

Repair of bony defect with combination biomaterials.

Background: Numerous possibilities are available for the reconstruction of facial bone defects. The materials used to fill such defects must satisfy various requirements. One of the most important is that they must undergo transformation into autologous bone tissue in the process of remodeling.

[SIMS (secondary ion mass spectroscopy) and XPS (x-ray photoelectron spectroscopy) study of titanium implant surfaces coated with anodic titanium-oxide layer].

The demands that must be satisfied by titanium implants applied in medical practice include chemical and physical durability. An anodic oxide protective layer formed on the surface of titanium implants serves for the better attainment of this aim. The composition of the passivizing layer and the changes in its thickness and binding state can be studied by method of material science, e.

[Bone substitution and remodeling of the jaw bones. A review].

Replacement of defects of the jawbones is one of the rapidly developing fields of maxillofacial surgery. The main criterion for the success of bone replacement is effective remodelling, i.e.

[About remodelling in connection with two cases of bone substitution].

Numerous possibilities are available for the reconstruction of facial bone defects. The materials utilized to fill such defects must satisfy various requirements. One of the most important being that they must undergo transformation into autologous bone tissue in the process of remodelling.

[Clinical comparison of graft materials used for sinus elevation].

Augmentation of the base of the maxillary sinus is one of the surgical procedures utilized in preparation for artificial root implantation in the maxilla. The authors intended to survey the causes of the lack of success (graft loss and implant failure) of sinus elevations with various graft materials or their combinations.

[Correction of maxillary atrophy with onlay-plasty].

Following tooth loss, augmentation of the extensively atrophized alveolar ridge of the maxilla may be necessary, in order to restore the masticatory function by the replacement of teeth anchored on implants. A number of bone augmentation methods are available for the acceptance of implants. The aim of the presented report is to summarize our experience relating to the use of free monocortical bone grafts originating from the hip (spina iliaca anterior superior) for purposes of onlay-plasty.

[Complication connected with sinus elevations].

Following tooth loss it may be necessary to increase the amount of bone at the maxillary alveolar ridge into which dental implants are to be inserted. Augmentation of the maxillary sinus is performed for this purpose. It may be considered as a routine intervention, but like all surgical methods, it involves certain risks.

Removal of titanium plates coated with anodic titanium oxide ceramic: retrospective study.

Transformation of the surface of metallic titanium with titanium oxides prepared in various ways is a modern procedure. For more than 15 years, the authors have been utilizing fixing elements coated with titanium oxide ceramics, prepared by anodic oxidation and thermal treatment, for purposes of jawbone osteosynthesis. The aim of the authors' work was to assess the extent to which the titanium oxide ceramic coating influences the fate of the plates used for osteosynthesis within the human organism, in regard to the possible need for their removal.