Experimental evaluation of absolute quantification in Tc-TRODAT-1 SPECT/CT brain dopamine transporter (DAT) studies.

Objective: To evaluate the quantitative accuracy of clinical brain dopamine transporters (DAT) investigations utilizing Tc-TRODAT-1 single-photon emission computed tomography (SPECT)/computed tomography (CT) in experimental and clinical settings.

Materials And Methods: The study used an experimental phantom evaluation and a clinical dataset. Three-dimensional-ordered subsets expectation-maximization reconstructed the original and resampled datasets using attenuation correction, scatter correction, and resolution recovery.