Recipient clinical risk factors predominate in possible transfusion-related acute lung injury.

Background: Possible transfusion-related acute lung injury (pTRALI) cases by definition have a clear temporal relationship to an alternative recipient risk factor for acute respiratory distress syndrome (ARDS). We questioned whether transfusion factors are important for the development of pTRALI.

Study Design And Methods: In this nested case-control study, we prospectively identified 145 consecutive patients with pTRALI and randomly selected 163 transfused controls over a 4-year period at the University of California at San Francisco and the Mayo Clinic (Rochester, Minnesota).

Prospective study on the clinical course and outcomes in transfusion-related acute lung injury*.

Objective: Transfusion-related acute lung injury is the leading cause of transfusion-related mortality. A prospective study using electronic surveillance was conducted at two academic medical centers in the United States with the objective to define the clinical course and outcomes in transfusion-related acute lung injury cases.

Design: Prospective case study with controls.

Cancer Incidence and Mortality in a Cohort of US Blood Donors: A 20-Year Study.

Blood donors are considered one of the healthiest populations. This study describes the epidemiology of cancer in a cohort of blood donors up to 20 years after blood donation. Records from donors who participated in the Retroviral Epidemiology Donor Study (REDS, 1991-2002) at Blood Centers of the Pacific (BCP), San Francisco, were linked to the California Cancer Registry (CCR, 1991-2010).

Genetic research in the blood bank: acceptability to Northern California donors.

Background: Blood banks have large altruistic donor populations and existing infrastructure that make them attractive sites for genetic epidemiologic research, but donors' willingness to participate and the impact on blood donation are unknown.

Study Design And Methods: A total of 2162 blood donors in Northern California responded to a cross-sectional questionnaire in August and September 2007. Participants were asked their likelihood of participation and future blood donation under three different scenarios: identity-linked genetic research, identity-unlinked genetic research, and genetic testing as a service.

Blood donor satisfaction and intention of future donation.

Background: New regulatory requirements for donor eligibility challenge blood centers to recruit and retain enough donors. This study evaluated correlations between overall satisfaction with the donation process and donor demographics and the effect of both on a donor's intent to return.

Study Design And Methods: An anonymous, self-administered questionnaire was given to donors at multiple sites of one blood center over a 3-week period.

The consequences of temporary deferral on future whole blood donation.

Background: The consequences of temporary deferral are not well understood. This study sought to investigate blood donor return after deferral expiration.

Study Design And Methods: A retrospective cohort analysis of allogeneic whole-blood donation was conducted.

Quantifying losses to the donated blood supply due to donor deferral and miscollection.

Background: Donors are deferred for multiple reasons. Losses related to disease marker rates are well established. Donor and donation losses for other reasons, however, have not been extensively quantified.