Tribolium castaneum defensin 1 kills Moraxella catarrhalisin an in vitro infection model but does not harm commensal bacteria.

is a bacterial pathogen that causes respiratory tract infections in humans. The increasing prevalence of antibiotic-resistant strains has created a demand for alternative treatment options. We therefore tested 23 insect antimicrobial peptides (AMPs) for their activity against in a human infection model with primary macrophages, and against commensal bacteria.

Antibacterial activity of a defensin in an infection model of .

() is the most common bacterial cause of community-acquired pneumonia. Increasing rates of antibiotic-resistant strains impair therapy and necessitate alternative treatment options. In this study, we analysed insect-derived antimicrobial peptides (AMPs) for antibacterial effects on in a human infection model.