Generalized Epilepsy and Myoclonic Seizures in 22q11.2 Deletion Syndrome.

Prompted by the observations of juvenile myoclonic epilepsy (JME) in 22q11.2 deletion syndrome (22q11DS) and recurrent copy number variants in genetic generalized epilepsy (GGE), we searched for further evidence supporting a possible correlation of 22q11DS with GGE and with myoclonic seizures. Through routine diagnostics, we identified 3 novel individuals with the seemingly uncommon combination of 22q11DS and JME.

[Anorexia nervosa as differential diagnosis in underweight patients].

Anorexia nervosa is a differential diagnosis in underweight patients, especially in young underweight women. Diagnostic criteria for anorexia nervosa are self-induced weight loss due to restrictive eating or purging behaviour, intense fear of gaining weight and disturbance in the way in which one`s shape is experienced, undue influence of body weight on self-evaluation and persistent lack of recognition of the seriousness of the current low body weight. Anorexia nervosa is associated with numerous medical complications.

[Anxiety driven atypical eating disorder in the course of phenylketonuria].

History And Admission Findings: Phenylketonuria is the most common genetic disease in amino acid metabolism. We report the case of a 22-year old patient with phenylketonuria and psychological symptoms. After early treatment, phenylalanine levels had been controlled and were within target area.

Olfactory deficits in patients with anorexia nervosa.

Background: Patients with anorexia nervosa (AN) often show gastrointestinal symptoms and have altered gastrointestinal functions. Olfaction is part of the predigestive function and plays an important role in the selection of food and the control of food intake. The question arises if patients with eating disorders have changes in olfactory functions as well.

[When eating becomes a disease - Binge-eating-disorder as comorbid eating disorder in obesity - Case 07/2009].

History And Admission Findings: A 30-year-old obese female patient with binge eating behaviour, depressive symptoms and poorly regulated diabetes mellitus was admitted to the department of psychosomatic medicine and psychotherapy

Investigations: The body mass index at time of admission was 38 kg/m(2). Fasting and postprandial blood glucose values were markedly increased. HbA(1c) level was 10.

Vomiting and feeling fat--coincidence of achalasia and bulimia nervosa.

Objective: In clinical practice it is often difficult to distinguish between organic and psychological vomiting.

Method: We present a case of a 34-year-old woman with an 18-month history of vomiting with the initial diagnosis of bulimia nervosa (BN). However, the patient showed an unusual vomiting behavior.

Brain imaging of visceral functions in healthy volunteers and IBS patients.

From experience, most people know about a link between psychological processes and gastrointestinal sensory and motor functions. Cognitive processes (e.g.

[Psychotherapy in obesity--a systematic review].

Obesity is a serious chronic disease, associated with severe sequelae and increased mortality rates, and therefore requires long-term care. This article gives an overview of the current state of research on psychotherapeutic treatment of obesity, focusing on behavioral approaches. Systematic well-controlled studies on humanistic and psychodynamic therapies are not available.

Psychological burden of food allergy.

One fifth of the population report adverse reactions to food. Reasons for these symptoms are heterogeneous, varying from food allergy, food intolerance, irritable bowel syndrome to somatoform or other mental disorders. Literature reveals a large discrepancy between truly diagnosed food allergy and reports of food allergy symptoms by care seekers.

Localizing and lateralizing language in patients with brain tumors: feasibility of routine preoperative functional MR imaging in 81 consecutive patients.

Purpose: To prospectively assess the feasibility of standardized presurgical functional magnetic resonance (MR) imaging for localizing the Broca and Wernicke areas and for lateralizing language function.

Materials And Methods: The study was approved by the responsible ethics commission, and patients gave written informed consent. Eighty-one patients (36 female and 45 male patients; age range, 7-75 years) with different brain tumors underwent blood oxygen level-dependent functional MR imaging at 1.

Gastrointestinal disturbances in eating disorders: clinical and neurobiological aspects.

Symptoms of the upper and lower gastrointestinal (gastrointestinal) tract have been described in anorexia nervosa and bulimia nervosa. Studies focusing on general outcome and medical comorbidity describe a worse outcome in the binge eating/purging subtype of anorexia nervosa compared to the restricting subtype. Both anorexia nervosa subtypes experience substantial delays in gastric emptying as well as constipation.

Functional cortical imaging of nausea and vomiting: a possible approach.

From a naive point of view, a study on functional cortical imaging of nausea and vomiting should deliver insight into the basic cortical mechanisms, connections, and time courses, of nausea and vomiting as perceived and processed in the human brain of affected subjects. Until now the brain's response to nausea and vomiting are only inadequately characterized, because studies have been focused mostly on understanding the different mechanisms leading to nausea rather than to cortical activations during nausea or vomiting, respectively. Consequently, the imaging of the "personal experience" of nausea and vomiting can currently be regarded as terra incognita.