The within-host ecology of insects and their parasites: integrating experiments and mathematical models.

The within-host ecology of hosts and their microbes involves complex feedbacks between the host immune system, energetic resources, and microbial growth and virulence, which in turn affect the probability of transmission to new hosts. This complexity can be challenging to address with experiments alone, and mathematical models have traditionally played an essential role in disentangling these processes, making new predictions, and bridging gaps across biological scales. Insect hosts serve as uniquely powerful systems for the integration of experiments and theory in disease biology.