Publications by authors named "Nora Horn"
[This corrects the article DOI: 10.1055/a-2196-6224.].
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- Pregnant women with COVID-19 face higher risks of severe complications, especially those with multiple pregnancies due to physical changes in lung function caused by the growing fetus.
- A study analyzed outcomes in 5514 women with symptomatic COVID-19 during pregnancy, focusing on the difference between those with multiple pregnancies and those with singletons.
- Results showed that while the overall incidence of adverse outcomes was similar, multiple pregnancies had earlier onset of complications and certain factors like high preconceptional BMI significantly increased risks.
Article Synopsis
- The study aimed to investigate the impact of long-term spermidine supplementation on memory performance in older adults (ages 60 to 90) with subjective cognitive decline, as part of a randomized trial conducted in Germany.
- Participants were divided into two groups, with one receiving a spermidine-rich supplement and the other a placebo, over a span of 12 months, with 89 out of 100 completing the trial.
- The primary measure of success was changes in memory performance, specifically through a test known as the Mnemonic Similarity Task, alongside secondary measures assessing various cognitive and physiological parameters.
Subjective cognitive decline (SCD), as expressed by older adults, is associated with negative affect, which, in turn, is a likely risk factor for Alzheimer's Disease (AD). This study assessed the associations between negative affective burden, cognitive functioning, and functional connectivity in networks vulnerable to AD in the context of SCD. Older participants (60-90 years) with SCD (n = 51) and healthy controls (n = 50) were investigated in a cross-sectional study.
View Article and Find Full Text PDFSubjective cognitive decline (SCD) is considered an early risk stage for dementia due to Alzheimer's disease (AD) and the development of pathological brain changes, such as the aggregation of amyloid-beta (amyloid-β) plaques. This study evaluates the association between specific features of SCD and cerebral amyloid-β load measured by positron emission tomography (PET) with F-florbetaben in 40 cognitively normal older individuals. Global amyloid-β, as well as regional amyloid-β load for the frontal, temporal, parietal, and cingulate cortex, was quantified.
View Article and Find Full Text PDFBackground: The natural polyamine spermidine, known to be important for cellular function, decreases during aging. Previous research has demonstrated beneficial impact of spermidine intake on memory functions in both animal models and humans, suggesting that spermidine may be a preventive approach to delay age-related cognitive decline and possibly even Alzheimer's disease (AD). However, the association of spermidine intake with brain health in humans is still unknown.
View Article and Find Full Text PDFBackground: Given the global increase in the aging population and age-related diseases, the promotion of healthy aging is one of the most crucial public health issues. This trial aims to contribute to the establishment of effective approaches to promote cognitive and brain health in older individuals with subjective cognitive decline (SCD). Presence of SCD is known to increase the risk of objective cognitive decline and progression to dementia due to Alzheimer's disease.
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