Publications by authors named "Nora Fekete"
Background: Fabry disease is a progressive, X chromosome-linked lysosomal storage disorder with multiple organ dysfunction. Due to the absence or reduced activity of alpha-galactosidase A (AGAL), glycosphingolipids, primarily globotriaosyl-ceramide (Gb3), concentrate in cells. In heterozygous women, symptomatology is heterogenous and currently routinely used fluorometry-based assays measuring mean activity mostly fail to uncover AGAL dysfunction.
View Article and Find Full Text PDFPancreatic adenocarcinoma is one of the tumours with the worst prognosis, with a 5-year survival rate of 5-10%. Our aim was to find and optimise peptide-based drug conjugates with daunorubicin (Dau) as the cytotoxic antitumour agent. When conjugated with targeting peptides, the side effect profile and pharmacokinetics of Dau can be improved.
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- - Immune checkpoint inhibitors, particularly anti-PD-1 monoclonal antibodies, can enhance T-cell activity against cancer but may also cause heart issues like myocarditis and cardiotoxicity, prompting research into their effects on cardiac function.
- - In experiments using mice, anti-PD-1 treatment led to cardiac dysfunction and increased inflammation in the thymus, particularly with heightened IL-17A levels, while other inflammatory markers remained mild.
- - Notably, blocking IL-17A prevented the cardiac dysfunction associated with PD-1 inhibition, suggesting that targeting IL-17A could mitigate the heart-related side effects of immune checkpoint therapy in cancer treatment.
Article Synopsis
- tBHQ, an antioxidant food additive, may influence immune responses to influenza and SARS-CoV-2 by altering gene expression.
- In experiments with mice, tBHQ treatment led to significant changes in 269 genes related to virus entry and interferon signaling for both viruses.
- The findings show that tBHQ could affect processes linked to respiratory viral infections, indicating its potential role in modulating immune functions.
It has previously been shown that preeclampsia is associated with disturbed hemostasis and that extracellular vesicles (EVs) play important role in the regulation of hemostatic homeostasis. Thus, we hypothesized that the altered procoagulant characteristics of circulating platelet-derived EVs may contribute to the disturbed hemostasis in preeclampsia. Using multicolor flow cytometry, we have analyzed both tissue factor expressing procoagulant EVs and platelet-derived EV subpopulations derived from resting and activated thrombocytes by examining them in plasma samples of preeclamptic patients and pregnancy-matched healthy individuals.
View Article and Find Full Text PDFRegulatory T cells (T) are mandatory elements in the maintenance of human pregnancy, but their de novo differentiation has not been completely exposed. HSPE1 chaperone expressing trophoblast cells may have a role in it. Trophoblast-derived extracellular vesicles (EVs), either at the feto-maternal interface or in circulation, target CD4 T cells.
View Article and Find Full Text PDFA correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
View Article and Find Full Text PDFIntercellular communication via extracellular vesicles (EVs) and their target cells, especially immune cells, results in functional and phenotype changes that consequently may play a significant role in various physiological states and the pathogenesis of immune-mediated disorders. Monocytes are the most prominent environment-sensing immune cells in circulation, skilled to shape their microenvironments via cytokine secretion and further differentiation. Both the circulating monocyte subset distribution and the blood plasma EV pattern are characteristic for preeclampsia, a pregnancy induced immune-mediated hypertensive disorder.
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