Intraoperative mitomycin and corneal endothelium after photorefractive keratectomy.

Purpose: To determine whether there is an increased risk to the corneal endothelium when mitomycin C (MMC) is administered after photorefractive keratectomy (PRK).

Design: Prospective, randomized, double-blind, placebo-controlled crossover trial.

Methods: Corneal endothelium was analyzed preoperatively and postoperatively in 18 eyes of nine patients who were administered either MMC- or balanced salt solution (BSS)-supplemented PRK at Codet Aris Vision, Tijuana, Mexico.