Publications by authors named "Nora A Alfadda"

Article Synopsis
  • The study explored the effects of the GLP-1 receptor agonist liraglutide on plasma protein profiles in patients with obesity, finding significant changes in weight, BMI, and HbA1c after three months of treatment.
  • A total of 151 proteins showed significant dysregulation, with 31 being upregulated and 120 downregulated post-treatment, highlighting potential biomarkers like Cystatin-B and multimerin-2.
  • Pathway analysis revealed major signaling pathways involved, particularly MAPK, AKT, and PKc, which play a crucial role in cell communication and could inform future obesity treatments.
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Background: Non-alcoholic fatty liver disease (NAFLD) is an overlooked complication of type 2 diabetes (T2D). Current recommendations for the management of NAFLD are mainly focused on weight reduction, overlooking the role of macronutrient composition. Although dietary carbohydrates play a major role in intrahepatic fat synthesis, their association with the progression of liver steatosis has not been fully investigated in patients with T2D.

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Background: Obesity is considered a global chronic disease requiring weight management through lifestyle modification, pharmacotherapy, or weight loss surgery. The dramatic increase in patients with severe obesity in Saudi Arabia is paralleled with those undergoing bariatric surgery. Although known to be beneficial in the short term, the long-term impacts of surgery within this group and the sustainability of weight loss after surgery remains unclear.

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Background: Few studies have reported valid comprehensive data on lifestyle habits of Saudi college females. In addition, studies on sedentary behaviors (SBs) and the duration of sleep of Saudi college students are rare. Saudi females appear to be less physically active and therefore, at a higher risk of noncommunicable diseases (NCDs).

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