Publications by authors named "Noortje I Regensburg"
Aim: To describe volumes of orbital fat (FV) and extraocular muscles (MV) in Graves' orbitopathy (GO) as a function of the duration of GO.
Patients: i) Cross-sectional survey among 95 consecutive patients with untreated GO who had been referred to the combined thyroid-eye clinics of our university hospital. ii) Longitudinal survey among 39 of the 95 patients who did not receive any therapeutic intervention and were followed for 1 year.
Graves' ophthalmopathy (GO) is characterized by swelling of orbital fat and extraocular muscles, but little attention has been given to differential involvement of fat and muscles. Advancements in imaging allow rather accurate measurements of orbital bony cavity volume (OV), fat volume (FV) and muscle volume (MV), and are the topics of this review. Ratios of FV/OV and MV/OV neutralize gender differences.
View Article and Find Full Text PDFDensities of orbital fat and extraocular muscles in graves orbitopathy patients and controls.
Ophthalmic Plast Reconstr Surg
September 2011
Purpose: To investigate CT densities of orbital soft tissue volumes in patients with Graves orbitopathy (GO) and to compare these with the densities of controls.
Methods: Observational case series. Of 95 patients with GO and 150 controls, soft tissue volumes, mean densities, and ratios of fat volume to orbital volume and muscle volume to orbital volume were calculated with software.
Background: Smoking adversely affects the course and severity of Graves' orbitopathy (GO). Cigarette smoke enhances adipogenesis in cultured human orbital fibroblasts. The present study tested our hypothesis that smoking is associated with increased orbital fat in GO patients.
View Article and Find Full Text PDFBackground: To investigate the natural history and the growth rate of spheno-orbital meningiomas (SOMs).
Methods: Ninety patients with a diagnosis of SOM were included, and patient charts and imaging were evaluated. In a subset of 32 patients, volumetric studies were performed.
Purpose: To describe the prevalence of fat and muscle volume (MV) increase in Graves' orbitopathy (GO) patients, calculated from computed tomography scans, and the associated ophthalmic and endocrine characteristics.
Design: Consecutive, observational case series.
Participants: Ninety-five consecutive Caucasian GO patients attending the thyroid eye clinic.
Purpose: To present and discuss the occurrence of a traumatic neuroma subsequent to inferomedial orbital decompression surgery in Graves' orbitopathy.
Methods: Case report.
Results: Approximately 1 month after surgery, a patient who underwent bilateral rehabilitative inferomedial orbital decompression developed a mass with clinical and radiologic characteristics compatible with a traumatic neuroma of the left infraorbital nerve.
Aim: To provide age and gender-specific reference values for orbital fat and muscle volumes (MV) in Caucasian adults.
Patients And Methods: Computed tomographic scans of 160 orbits from 52 men and 55 women, aged 20-80 years, not affected by orbital disease were evaluated. Orbital bony cavity volume (OV), fat volume (FV) and MV were calculated by a previously validated method using the software program Mimics.
Purpose: There is no consensus as how to calculate orbital soft tissue volume based on CT or MRI scans. The authors sought to validate their technique and to assess the intraobserver and interobserver variability of their calculations of bony orbital volume (OV), orbital fat volume (FV), and extraocular muscle volume (MV) on CT scans of humans.
Methods: The authors calculated these volumes with the use of a manual segmentation technique on CT scans with commercially available software.