Publications by authors named "Noormohamad Mansoori"
Background: The emergence of multidrug-resistant tuberculosis (MDR-TB) or rifampicin-resistant (RR) TB poses a significant challenge for TB control initiatives on a global scale. This study's aim was to estimate the incidence of MDR-/RR-TB and identify the risk factors associated with their incidence in four provinces in northern Iran.
Methods: Drug susceptibility testing was conducted using the proportion method on Lowenstein-Jensen media.
Background: There are limited data on the (MTB) drug resistance in regions located at the proximity of the Caspian Sea. We aimed to assess the drug resistance patterns of the MTB isolates to anti-tuberculosis drugs in patients from four northern provinces of Iran between April 2013 and March 2019.
Methods: Drug susceptibility testing (DST) was performed by culturing MTB isolates on the Lowenstein-Jensen medium using the proportion method.
The Xpert MTB/RIF assay (Xpert) is a molecular assay used for direct detection of Mycobacterium tuberculosis (MTB) in clinical specimens. In this study, we aimed to assess the accuracy of the Xpert assay for the diagnosis of tuberculosis (TB) in TB suspected patients from the northern region of Iran. The obtained results were compared with the culture method.
View Article and Find Full Text PDFIntroduction: Despite the moderate incidence of tuberculosis (TB) in many parts of Iran, Golestan province had a permanently higher TB incidence rate than the national average. Moreover, Golestan province receives immigrants, mainly from TB-endemic areas of Iran and neighbor countries. Here, we aimed to characterize the circulating complex (MTBC) isolates in terms of the spoligotype and drug resistance patterns, across Golestan province.
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- The study aimed to evaluate the genetic diversity of Mycobacterium tuberculosis (M.tb) and its association with infection sites in Iran, focusing on pulmonary vs. extrapulmonary tuberculosis.
- Researchers utilized Spoligotyping and MIRU-VNTR typing methods to analyze culture-confirmed PTB and EPTB isolates, revealing predominant genotypes and diverse patterns among samples.
- Results showed that the transmission rate of TB was low, indicating that most cases were due to reactivation of latent infections rather than new transmissions, with no significant link found between M.tb genotypes and disease location.
We aimed to determine the genetic diversity, phylogenetic relationship and transmission dynamics of Mycobacterium tuberculosis complex (MTBC) genotypes in an area with high tuberculosis (TB) incidence. A set of 164 MTBC isolates from new TB patients of Golestan province, Iran, were subjected to genotyping using the standard 24-locus MIRU-VNTR method. Recent TB transmission was evaluated and phylogenetic relationships were analysed by minimum spanning tree and cluster-graph methods.
View Article and Find Full Text PDFPurpose: The incidence of tuberculosis (TB) in Golestan province of Iran has been ranked 10th among countries of World Health Organization (WHO) Eastern Mediterranean Region. The province is residence of ethnically heterogeneous groups. However, there are limited data on Mycobacterium tuberculosis drug resistance in this province.
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- Multidrug-resistant Acinetobacter baumannii infections are a significant concern in clinical settings due to their ability to resist a variety of antibiotics.
- In a study of 91 A. baumannii isolates from intensive care units across Iran, researchers identified 24 genotypes, with 91.2% clustering into four main groups, including a widespread novel variant known as sequence group 7 (SG7).
- Resistance patterns showed varying levels of resistance to antibiotics: 14.2% to colistin, 20% to tigecycline, and 77% to rifampicin, while all isolates were susceptible to ampicillin-sulbactam and/or tobramycin.