Comparative Evaluation of the Preventive Effects of Citral, Silymarin, Thymoquinone, and Curcumin on 5-Fluorouracil-Induced Cardiac and Pulmonary Toxicity in Rats.

Objectives: 5-fluorouracil chemotherapy is a highly recommended treatment for different types of solid tumors. However, this treatment can have severe side effects on the heart and lungs. In this study, we compared the protective effects of citral, silymarin, thymoquinone, and curcumin against 5-fluorouracil-induced toxicity in the heart and lungs of rats.

Effects of Dietary Supplement of Basil Extract on Biochemical and Immunological Parameters and Growth Performance in .

has antioxidant, anti-inflammatory, and antimicrobial effects. The present study was conducted to evaluate the effects of extract on growth yield, safety, and marinating physiologic functions of the rainbow trout. The fish were fed with food rations containing 0%, 1%, 2%, and 3% of basil extract.

Comparative Study of the Protective Effects of Citral, Thymoquinone, and Silymarin on Methotrexate-induced Cardiotoxicity in Rats.

Objectives: Methotrexate (MTX), an immunosuppressant and anti-cancer medication, can harm the heart. The goal of the current investigation was to assess the cardiotoxicity caused by MTX and the potential cardioprotective properties of silymarin, citral, and thymoquinone as antioxidants.

Methods: Forty-eight rats were divided into six groups, which included control, MTX, cosolvent, citral, thymoquinone, and silymarin groups.

The hepatoprotective effects of sitagliptin against cyclophosphamide-induced hepatotoxicity in rat.

Hepatotoxicity is a serious side effects of cyclophosphamide. Thus, the present research investigates the protective properties of sitagliptin against cyclophosphamide-induced hepatotoxicity. Fifty male rats were randomly divided into five groups.

The Effects of Silymarin on Calcium Chloride-Induced Arrhythmia in Male Rat.

Antioxidants play an important role in protecting cardiac arrhythmias. Silymarin, strong antioxidant, is effective in reducing the complications caused by arrhythmias. This study was conducted to determine the effect of silymarin on the prevention and treatment of calcium chloride-induced arrhythmia.

Evaluation of the Protective Effect of Citral, Silymarin, and Thymoquinone on Methotrexate-Induced Lung Injury in Rats.

Objectives: Several studies have reported that methotrexate is an anti-cancer and immunosuppressive drug leading to lung injury. Therefore, the present study aimed to investigate the protective effects of silymarin, citral, and thymoquinone on methotrexate-induced pulmonary toxicity.

Methods: Forty-eight rats were divided into six groups, including healthy, Methotrexate, and drug carrier control groups and silymarin, citral, and thymoquinone treatment groups.

Protective Effects of Thymoquinon on Pulmonary Disorders in Experimental Studies.

Lung as vital organ is exposed to many injurious agents that can cause inflammation and oxidative stress, which are potential causes in the pathogenesis of lung diseases. usually introduced as black seed, has been considered for treatment of various diseases and is one the most widely investigated herbs. Thymoquinone (TQ) is the major component of the volatile oil of black seed (54%) which has been indicated to anti-oxidant, anti-inflammatory and anti-neoplastic properties.

An Overview on Renoprotective Effects of Thymoquinone.

Background: Kidneys as vital organs remove waste material from blood. Additionally, they may also have a role in the electrolyte balance, regulation of blood pressure, and red blood cell genesis. Kidney diseases may be caused by several factors such as ischemia/reperfusion injury, diabetes, and nephrotoxic agents.

An Overview of Hepatoprotective Effects of Thymoquinone.

Background: Liver diseases are globally recognized as major medical problems. Several species of herbal medicine have been investigated for the management of liver-related diseases.

Objective: In this context, Thymoquinone (TQ) as the main constituent of Nigella sativa has long been focused for the treatment of liver diseases in recent years.

Immunomodulatory and Anti-inflammatory Effects of Thymoquinone.

Background: The immunomodulatory properties of Nigella sativa seed, as a basis of its clinical applications by many cultures have been reviewed. Thymoquinone (TQ) is one of the major bioactive components of the volatile oil of N. sativa seeds.

Liver ischemia preconditions the heart against ischemia-reperfusion arrhythmias.

Objectives: This study aimed to examine the hypothesis that an antiarrhythmic effect might be obtained by ischemic preconditioning of the liver, and also to characterize the potential underlying mechanisms.

Materials And Methods: Male Wistar rats were anesthetized by thiopental sodium (50 mg/kg, IP) followed by IV injection of heparin (250 IU). Remote ischemic preconditioning (RIPC) was induced by 3 cycles of 5 min liver ischemia followed by 5 min of reperfusion.