INTRAVENOUS VATINOXAN IN MARKHORS () IMMOBILIZED WITH INTRAMUSCULAR MEDETOMIDINE AND KETAMINE-A PRELIMINARY DOSESCREENING STUDY.

Medetomidine is an α-2 adrenoceptor agonist commonly combined with ketamine for immobilization of nondomestic mammals. However, it may cause some remarkable adverse effects such as bradycardia, hypertension, and hypoxemia. Vatinoxan (previously called MK-467 and L-659,066) is an α-2 adrenoceptor antagonist that affects mostly the peripheral receptors due to its minimal ability to cross the blood-brain barrier.