Fibroblast-derived Gremlin1 localises to epithelial cells at the base of the intestinal crypt.

Gremlin1 (GREM1) is a secreted glycoprotein member of the differential screening-selected gene in aberrant neuroblastoma (DAN) family of bone morphogenetic protein (BMP) antagonists, which binds to BMPs preventing their receptor engagement. Previous studies have identified that stage II colorectal cancer (CRC) patients with high levels of gene expression in their tumour tissue have a poorer prognosis. Using a series of and methodologies, we demonstrate that gene expression is significantly higher ( < 0.