Publications by authors named "Noor E Taams"
Background And Objectives: Chronic axonal polyneuropathy is a common disease of the peripheral nervous system with increasing prevalence with age. Typical neurologic signs are present in patients with polyneuropathy but may also occur in individuals without disease. Owing to limited knowledge on normal aging of the peripheral nervous system, it can be difficult to distinguish peripheral nerve dysfunction due to disease from variations in normal aging.
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- Chronic axonal polyneuropathy is becoming more common with age and significantly impacts daily life, but many individuals do not seek medical help, leading to underreporting of its prevalence.
- A study conducted from 2013 to 2020 in the Netherlands included over 4,000 participants and found that the age-standardized prevalence of the condition was about 3% in Europe and the U.S., and projected to increase by 25% in the next 20 years.
- Many participants had undiagnosed polyneuropathy, with notable risk factors including diabetes and vitamin deficiencies, and over 20% of cases exhibited multiple risk factors.
Article Synopsis
- - The study explores how genetic factors related to diabetes, body mass index (BMI), vitamin B12 levels, and alcohol intake may be linked to chronic axonal polyneuropathy, a common nerve disease, using data from the Rotterdam Study involving 1,565 participants.
- - Findings reveal that higher polygenic scores (PGSs) for diabetes, BMI, and alcohol intake correlate with a greater prevalence of polyneuropathy, while higher PGSs for vitamin B12 levels are linked to a lower prevalence.
- - The results suggest a potential causal relationship between these clinical risk factors and polyneuropathy, reinforcing the need for further research on genetic influences in this condition.
Background And Purpose: Chronic axonal polyneuropathy is a common, usually multifactorial, disease for which there is no treatment yet available. We investigated the association between cardiovascular health, defined by the health score of the American Heart Association, and chronic axonal polyneuropathy.
Methods: Between June 2013 and January 2017, we investigated participants of the Rotterdam Study, a population-based cohort study.
Diet quality and chronic axonal polyneuropathy: a population-based study.
Ann Clin Transl Neurol
December 2019
Article Synopsis
- The study aimed to explore the link between diet quality and chronic axonal polyneuropathy among 1650 participants with an average age of 69.1 years.
- Researchers used food frequency questionnaires and various medical evaluations to assess diet quality and the presence of polyneuropathy.
- Results indicated no overall association between diet quality and polyneuropathy, but a notable finding suggested that salt intake of ≤6 g/day may be connected to a lower risk of this condition.
In this study, we evaluated the diagnostic value of symptoms of chronic polyneuropathy and to construct and validate a simple questionnaire that can help diagnose chronic polyneuropathy. In a multi-step procedure, we initially compiled a 12-item questionnaire concerning polyneuropathy symptoms. The questionnaire was completed by 117 polyneuropathy patients and 188 controls (headache, transient ischemic attack, multiple sclerosis).
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- Researchers found that anti-GD1b antibodies are present in some patients with immune-mediated neuropathies, particularly in Guillain-Barré syndrome (GBS) and Miller Fisher-GBS overlap syndrome (MF-GBS).
- Among various patient groups, IgG anti-GD1b antibodies were primarily observed in GBS (12.1%) and MF-GBS (14.3%), while IgM antibodies were found in lower frequencies.
- Patients with GBS or MF-GBS harboring only anti-GD1b antibodies showed quicker recovery in their walking ability compared to those with other antibody combinations, indicating potential clinical significance of anti-GD1b testing for diagnosis and treatment planning.
A 75-year-old man presented with a blistering skin disease and nephrotic syndrome. Bullous pemphigoid was diagnosed by linear immunoglobulin G (IgG) and C3 staining along the basement membrane zone of a skin biopsy specimen and by the presence of circulating IgG recognizing the 180-kDa bullous pemphigoid antigen (BP180; type XVII collagen). A kidney biopsy specimen showed endocapillary inflammation without crescents.
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