Publications by authors named "Nonoka Suzuki"
Background: Chronic kidney disease (CKD) causes progressive and irreversible damage to the kidneys. Renal biopsies are essential for diagnosing the etiology and prognosis of CKD, while accurate quantification of tubulo-interstitial injuries from whole slide images (WSIs) of renal biopsy specimens is challenging with visual inspection alone.
Methods: We develop a deep learning-based method named DLRS to quantify interstitial fibrosis and inflammatory cell infiltration as tubulo-interstitial injury scores, from WSIs of renal biopsy specimens.
Article Synopsis
- A 66-year-old man with severe kidney dysfunction was admitted to the hospital due to numerous stubborn skin ulcers, initially suspected to be calciphylaxis due to systemic arterial calcification.
- A skin biopsy revealed the actual diagnosis of cholesterol crystal embolization, prompting treatments like hemodialysis and steroids.
- Unfortunately, the patient died from multiple intestinal perforations, with an autopsy confirming blockage of organ arterioles by cholesterol crystals, highlighting the critical link between skin ulcers and serious underlying conditions in chronic kidney disease patients.