Publications by authors named "Nonoka Kashiwagi"
Article Synopsis
- The text discusses three types of peroxisome proliferator-activated receptors (PPARs) - PPARα, PPAR(ß/)δ, and PPARγ - and their role in gene transcription regulation through interactions with retinoid X receptors (RXRs)
- It highlights how ligand-bound PPAR/RXR complexes recruit specific coactivator proteins to gene regulatory locations, impacting gene expression, but emphasizes that each PPAR can interact with only one coactivator at a time via a specific motif (LXXLL)
- The study investigates the recruitment of various coactivators by different PPAR agonists intended for treating nonalcoholic fatty liver disease, finding that the efficacy and potency of co
