Publications by authors named "Nongyao Nontawong"
Nanoscale imprinting significantly increases the specific surface area and recognition capabilities of a molecularly imprinted polymer by improving accessibility to analytes, binding kinetics, and template removal. Herein, we present a novel synthetic route for a dual molecularly imprinted polymer (dual-MIP) of the carcinogen oxidative stress biomarkers 3-nitrotyrosine (3-NT) and 4-nitroquinolin-N-oxide (4-NQO) as coatings on graphene quantum-dot capped gold nanoparticles (GQDs-AuNPs). The dual-MIP was successfully coated on the GQDs-AuNPs core via a (3-mercaptopropyl) trimethoxysilane (MPTMS) linkage and copolymerization with the 3-aminopropyltriethoxysilane (APTMS) functional monomer.
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- A novel dual-imprinted electrochemical paper-based analytical device (Di-ePAD) has been developed to simultaneously measure biomarkers 8-OHdG and 3-NT in urine and plasma samples, enhancing detection of oxidative stress.
- The device utilizes a molecularly imprinted polymer (MIP) formed on a silica nanosphere decorated with silver nanoparticles, allowing for improved selectivity, conductivity, and catalytic activity in sensing analytes.
- The Di-ePAD demonstrates a wide detection range (0.01-500 μM for 3-NT and 0.05-500 μM for 8-OHdG) with low detection limits and shows good accuracy in real sample analysis compared to traditional methods like HPLC.
Article Synopsis
- Researchers developed a new sensor for detecting creatinine that uses copper oxide nanoparticles coated with a specialized polymer, enhancing sensitivity and response time.
- The sensor (CuO@MIP/CPE) shows strong electro-oxidation performance for creatinine detection, achieving a linear response from 0.5 to 200 μM and a low detection limit of 0.083 μM.
- It successfully detected creatinine in human urine samples, with good precision and minimal performance loss when stored properly.