Four new sesquiterpenoid derivatives from the heartwood of Mansonia gagei.

Four new sesquiterpenoid derivatives named mansonones N (1), O (2), P (3), and Q (4) were isolated from a dichloromethane extract of the heartwood of Mansonia gagei, a plant used in folk medicine in Thailand. Their structures were resolved on the basis of spectrometric data interpretation and the single-crystal X-ray analysis of 1 and 2.

Croblongifolin, a new anticancer clerodane from Croton oblongifolius.

A new furoclerodane, croblongifolin, together with one known clerodane, crovatin and one known labdane, nidorellol, were isolated from the stem bark of Croton oblongifolius. Structures were established based on spectroscopic and X-ray analysis. Croblongifolin showed a significant cytotoxicity against various human tumor cell lines including HEP-G2, SW620, CHAGO, KATO3 and BT474.