Publications by authors named "Nomun Ganjuur"
Article Synopsis
- The study focuses on women of childbearing age (WoCBA) with moderate-to-severe psoriasis, examining their treatment options based on their pregnancy plans.
- It compares two groups: those wishing to conceive (CB+) and those not planning to have more children (CB-), noting that there were no major differences in health-related quality of life but a higher use of certain treatments in the CB+ group.
- Results indicate that discussions about family planning were more frequent among the CB+ group, but overall patient-doctor agreement on treatment decisions was only fair-to-moderate, highlighting areas for improvement in shared decision-making.
Article Synopsis
- Telangiectasia is a key feature of rosacea, necessitating effective treatment and standardized assessment tools for clinical evaluations.
- The study aimed to create and validate the TRoSA scale, a five-point photonumeric system to evaluate telangiectasia severity in rosacea patients, using feedback from 16 experts and 50 patient images.
- Results showed that the TRoSA scale has high interrater and intrarater reliability, making it a reliable tool for consistent clinical assessments and treatment evaluations in rosacea.
Article Synopsis
- Angioedema is a serious reaction linked to ACE inhibitors, and its causes include genetic and non-genetic factors; recent studies have begun to uncover genetic risk factors but not the full underlying mechanisms.!* -
- Researchers analyzed data from over 1,000 European patients, discovering three significant genetic risk loci associated with ACEi-induced angioedema, one of which has not been previously noted.!* -
- The findings underscored the role of bradykinin signaling and coagulation pathways while suggesting new genetic candidates involved in angioedema, highlighting similar genetic effects in both European and African-American patients.!*
Angioedema is a relatively rare but potentially life-threatening adverse reaction to angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARBs). As with hereditary forms of angioedema (HAE), this adverse reaction is mediated by bradykinin. Research suggests that ACEi/ARB-induced angioedema has a multifactorial etiology.
View Article and Find Full Text PDFThere exist relatively sparse and conflicting data on high-level microsatellite instability (MSI-H) and deficient mismatch repair (dMMR) in cutaneous malignancies. We aimed to determine the expression profiles of MMR proteins (MSH2, MSH6, MLH1, and PMS2) in different progression stages of cutaneous squamous cell carcinoma (cSCC, 102 patients in total) by immunohistochemistry, and search for MSI-H in patients with low-level MMR or dMMR using multiplex-PCR. Low-level MMR protein expression was observed in five patients: One patient with primary cSCC < 2 mm thickness and low-level MLH1, three patients with primary cSCC > 6 mm (including one with low-level MSH2, as well as MSH6 expression, and two with low-level PMS2), and one patient with a cSCC metastasis showing low-level MSH2 as well as MSH6.
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