Publications by authors named "Nomerovskaya M"
Proteins belonging to the anoctamin (ANO) family form calcium-activated chloride channels (CaCCs). The most unusual member of this family, ANO6 (TMEM16F), simultaneously exhibits the functions of calcium-dependent scramblase and the ion channel. ANO6 affects the plasma membrane dynamics and phosphatidylserine transport; it is also involved in programmed cell death.
View Article and Find Full Text PDFCalcium chelation independent effects of BAPTA on endogenous ANO6 channels in HEK293T cells.
Biochem Biophys Res Commun
January 2024
Selective calcium chelator 1,2-Bis(2-aminophenoxy) ethane-N,N,N',N'-tetraacetic acid (BAPTA) is a common tool to investigate calcium signaling. However, BAPTA expresses various effects on intracellular calcium signaling, which are not related to its ability to bind Ca. In patch clamp experiments, we investigated calcium chelation independent effects of BAPTA on endogenous calcium-activated chloride channels ANO6 (TMEM16F) in HEK293T cells.
View Article and Find Full Text PDF1,2,3,4-dithiadiazole derivatives as a novel class of calcium signaling modulators.
Biochem Biophys Res Commun
January 2024
Article Synopsis
- * Researchers discovered that a specific compound, 3-(4-nitrophenyl)-5-phenyl-3H-1,2,3,4-dithiadiazole-2-oxide, significantly reduces calcium uptake by affecting store-operated calcium (SOC) channels, establishing a new class of inhibitors.
- * The study compared different derivatives of 1,2,3,4-dithiadiazoles, finding that two specific compounds were particularly effective at reducing SOC entry, highlighting the role of certain chemical substituents in enhancing their inhibitory effects.