Publications by authors named "Nolwenn Lucas"
Article Synopsis
- Acute abdominal complications (AAC) in patients with deep neutropenia (DN) pose significant management challenges, particularly affecting prognosis and increasing surgical risks.
- In a study of 105 patients over ten years, 17% needed emergency surgery due to AAC, revealing varying mortality rates among different treatment groups.
- Despite high mortality (50% in the surgical group), some patients achieved long-term survival after surgery, indicating that surgery may be beneficial in selected cases of unpreventable emergencies.
Donor Lymphocyte Infusions After Allogeneic Transplantation: A Single-Center Experience.
Clin Lymphoma Myeloma Leuk
April 2020
Allogeneic hematopoietic cell transplantation (AHCT) represents the only curative therapy for many hematological malignancies. The graft versus leukemia effect, driven by donor T cells, plays a major role in its curative potential. This effect is sometimes very evident when patients with acute myeloid leukemia and myelodysplasia relapse after AHCT and are treated with donor lymphocyte infusions (DLIs).
View Article and Find Full Text PDFIslands of CD123 cells have been commonly described in the bone marrow of patients with chronic myelomonocytic leukemia (CMML). Using a multiparameter flow cytometry assay, we detected an excess of CD123 mononucleated cells that are lineage-negative, CD45, CD11c, CD33, HLA-DR, BDCA-2, BDCA-4 in the bone marrow of 32/159 (20%) patients. Conventional and electron microscopy, flow cytometry detection of cell surface markers, gene expression analyses, and the ability to synthesize interferon alpha in response to Toll-like receptor agonists identified these cells as bona fide plasmacytoid dendritic cells (pDCs).
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- Chronic myelomonocytic leukemia (CMML) is a type of cancer that affects blood cells and is linked to inflammation.
- Researchers found differences in levels of certain substances called cytokines between CMML patients and healthy people, with some cytokines being higher in the patients.
- The study shows that the level of a specific cytokine called IL-10 can help predict how well patients with CMML will do in the future, making it important for understanding and treating this disease.
Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic disorder that associates dysplastic and proliferative features. Tissue inflammatory disorders occur in a fraction of CMML patients during the course of their disease. Here, we describe the occurrence of eosinophil-rich tissue inflammation, including eosinophilic pneumonia, chondritis, and cystitis, in CMML patients.
View Article and Find Full Text PDFChronic Myelomonocytic Leukemia is a chronic myeloid neoplasm occurring mostly in the elderly with overlapping features of myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPN) characterized by chronic monocytosis. Recent progresses in the molecular and cellular pathogenesis of CMML have stirred a renewed interest in this clinically heterogeneous disorder. Here, we review the recent progresses in the biology of CMML and how it affects its current and future clinical management.
View Article and Find Full Text PDFA novel series of benzimidazole NR2B-selective NMDA receptor antagonists.
Bioorg Med Chem Lett
April 2012
A series of novel benzimidazoles are discussed as NR2B-selective N-methyl-d-aspartate (NMDA) receptor antagonists. High throughput screening (HTS) efforts identified a number of potent and selective NR2B antagonists such as 1. Exploration of the substituents around the core of this template identified a number of compounds with high potency for NR2B (pIC(50) >7) and good selectivity against the NR2A subunit (pIC(50) <4.
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