Long-term neurobehavioral outcome in pediatric brain-tumor patients: review and methodological critique.

This paper provides an overview of pediatric brain tumors and reviews the literature on long-term neurobehavioral outcomes for these children. Progress in this area has been slow due to numerous methodological and practical complications. While some general conclusions can be drawn, the development of comprehensive models awaits more research into the multiplicity of biological and nonbiological events, and their interactions, potentially affecting outcome.

Mealtime interactions and family relationships of families with children who have cancer in long-term remission and controls.

This study investigated reports of parents (mothers and fathers) of 25 children with cancer in long-term remission and matched neighborhood control families on issues related to the quality of mealtime interactions, and the relationship between parental reports of overall family functioning and the quality of mealtime interactions. Results showed positive correspondence for both groups between fathers' and mothers' reports of favorable family environments (greater cohesion and expressiveness, less conflict) and positive mealtime interactions. No significant differences were found between parents of children with cancer and control parents with regard to mealtime conflicts, current concerns about their child's eating, or satisfaction with the child's food intake.

Adjustment in the peer system of adolescents with cancer: a two-year study.

Evaluated the psychosocial adaptations of adolescents with cancer who were primarily off treatment (n = 19, ages 11-18) as compared with matched classroom controls in a 2-year longitudinal study on indices of (a) teacher, peer, and self-perceptions of social reputation; (b) multiple measures of popularity and friendships; and (c) self-reported feelings of loneliness, depression, and self-concept. Adolescents with cancer continued to have a social reputation as being more socially isolated, but no significant differences were identified on multiple measures of social acceptance or the self-reported feelings. In general, adolescents with cancer were similar to peers on numerous dimensions of psychological functioning manifesting minimal discernable psychosocial late effects.

Predictors of behavior problems in three-year-old sons of alcoholics: early evidence for the onset of risk.

We investigated risk factors in a population-based sample of alcoholic (father) and comparison families with 3-year-old sons. Alcoholic and comparison parents did not differ in socioeconomic status (SES), education, years married, family size, or cognitive functioning. Antisocial behavior and depression were significantly greater in alcoholic parents.

Social interactions between children with cancer or sickle cell disease and their peers: teacher ratings.

We evaluated the social reputation of children with cancer (nonprimary brain tumors) (n = 26) children with a primary malignancy involving the central nervous system (n = 15), and children with sickle cell disease (SCD) (n = 33) using a standardized measure of social reputation, the Revised Class Play (RCP). Each child's classroom teacher completed the RCP, an instrument designed to assess sociability-leadership, aggressive-disruptive, and sensitive-isolated interpersonal qualities. Matched-pairs analyses comparing the child with chronic illness to one peer in each class who was the same gender/race and the closest date of birth showed children with cancer were nominated more often for sociability-leadership roles and less often for aggressive-disruptive roles.

Alcohol expectancies and behavioral and emotional responses to placebo versus alcohol administration.

Forty normal drinking males were recruited for a study of "responses to alcohol." Following the completion of an alcohol use questionnaire that included measures of expectancies of alcohol effects, subjects were randomly assigned to either receive the actual 0.6 g/kg dose of ethanol to bring their peak blood alcohol concentration (BAC) to near 0.

CNS prophylaxis of childhood leukemia: what are the long-term neurological, neuropsychological, and behavioral effects?

Current medical treatments for childhood acute lymphoblastic leukemia (ALL) have improved the outlook to where more than 50% can be expected to survive five years or more. The use of CNS prophylaxis has contributed in a significant way to these improved survival statistics by reducing the likelihood of CNS relapses. The literature relating to the potential adverse psychological consequences of CNS prophylaxis, which include cranial radiation therapy (CRT), is reviewed and analyzed.

Peer relationships and adjustment in children with cancer.

Evaluated the psychosocial adaptations of children with cancer (n = 24, ages 8-18) as compared with same classroom controls on indices of (a) peer- and self-perceptions of sociability, aggression, and social isolation; (b) overall popularity; (c) mutual friendships; (d) feelings of loneliness; and (e) self-concept in multiple domains. Although the peer report data showed that children with cancer had a social reputation as significantly more socially isolated, no significant differences were found for their popularity, number of mutual friends, loneliness, or self-worth. Findings suggest that children with cancer have a reputation as more socially isolated, but differences were not found on measures of acceptance by peers, self-concept, or loneliness.

Differences in the child-rearing practices of parents of children with cancer and controls: the perspectives of parents and professionals.

Obtained self-reports of parenting practices from fathers and mothers of 24 children with cancer, and 24 controls using the Child-Rearing Practices Report (CRPR). Cancer patients were primarily in long-term remission and represented a typical pattern of childhood malignancies. Same age/sex controls were recruited from the classrooms of the children with cancer.

Identification of alcohol by smell among preschoolers: evidence for early socialization about drugs occurring in the home.

This study tested preschoolers' ability to provide accurate verbal associations to alcoholic beverage odors and whether this ability was related to parental drinking patterns and motivations. Older preschoolers performed better than younger preschoolers; photographic cues improved performance; children who correctly identified a substance by smell had socially appropriate knowledge of the culturally appropriate users of the substance; children reported liking substances that are used mainly by children and adults, and generally reported disliking substances whose use is legally limited to adults only; children were better at identifying substances they commonly use, but success at recognition of alcoholic beverages was related to heavier parental drinking and use of alcohol for escape reasons. Findings have implications for theories of socialization to drug use and for models of prevention.

Social interactions between children with cancer and their peers: teacher ratings.

Compared children (ages 8-18) with cancer (n = 24) and matched classroom control children (n = 24) using a modified version of the Revised Class Play (RCP). A wide variety of malignancies were represented, except brain tumors. Childrens' classroom teachers completed the RCP, an instrument modified to obtain teachers' impressions of three fundamental dimensions of interpersonal style: sociability-leadership, aggressive-disruptive, sensitive-isolated.

Multiple personality, dissociation, and C.G. Jung's complex theory.

Jung's contributions to the study of 'dissociation' are outlined here for perhaps the first time. Jung is unique in recognising that the 'dissociability of the psyche' is a fundamental process that extends along the continuum from 'normal' mental functioning to 'abnormal' states. Dissociation is recognised by Jung as a universal and necessary psychic activity for the development of personality through the differentiation of functions.

Adaptive neural network in a hybrid optical/electronic architecture using lateral inhibition.

We report the optical implementation of a neural network based on a nearest matched filter algorithm and extensive lateral inhibition. Extremely rapid learning is demonstrated in pattern recognition and autonomous control applications, without introducing processing artifacts such as spurious states and ambiguous solutions. The optical implementation is achieved with a reconfigurable, bipolar mask-type crossbar switch based on an inexpensive liquid crystal spatial light modulator.

Long-term follow-up of biochemical and cognitive functioning in patients with mannosidosis.

Longitudinal assessments of three brothers with alpha-mannosidosis were performed biochemically by determining levels of leukocyte enzyme activity, and neurodevelopmentally by testing of general intelligence, language, visual spatial skills, and overall adaptive abilities. During the follow-up examination, enzyme activity was assessed in fibroblasts to evaluate the uniformity of biochemical deficits. The biochemical findings demonstrated profound deficits of leukocyte alpha-mannosidase that remained remarkably stable over time and were very similar to levels of the same enzyme activity in fibroblasts.

Reconfigurable bipolar analog optical crossbar switch.

A differential technique is proposed for obtaining bipolar analog {-1 . . .

What has really been learned about shamanism?

Within anthropology, investigations of shamans and their altered states of consciousness have followed some of the prescriptive problems inherited from the discipline of psychology, coloring the assumptions and perspectives of students of shamanism. These inherited problems include the following: conscious/volitional versus unconscious/involuntary mentalisms; contentual objectivism versus contentual subjectivism; environmentalism versus nativism; monopsychism versus polypsychism; mechanism versus vitalism; and quantitativism versus qualitativism. Although the polemics of anthropological studies of shamanism have reflected these prescriptive perspectives, this has not inhibited the acquisition of new knowledge about shamanism.

Hypnotherapy of a child with warts.

Hypnosis was used to treat a 7-year-old female with 82 common warts. The lesions had been present for 12-18 months and were refractory to routine dermatologic treatment. Hypnotic suggestions were given for the facial warts to disappear before warts from the rest of the body.

Computer simulation of schlieren images of rotationally symmetric plasma systems: a simple method.

Schlieren techniques are commonly used methods for quantitative analysis of cylindrical or spherical index of refraction profiles. Many schlieren objects, however, are characterized by more complex geometries, so we have investigated the more general case of noncylindrical, rotationally symmetric distributions of index of refraction n(r,z). Assuming straight ray paths in the schlieren object we have calculated 2-D beam deviation profiles.

Follow-up of language and cognitive development in patients with mannosidosis.

Three brothers with mannosidosis were assessed both biochemically by levels of enzyme activities and developmentally by serial testing of language and cognitive development. The findings indicated that while the leukocyte enzyme activity of alpha-mannosidase was exceptionally low, only mild intellectual deficits were present that did not progress during a two-year follow-up. These results do not substantiate the expected relationship between the severities of enzyme deficiency and developmental delays.

Laminectomy: effects on postoperative technetium and gallium scintigraphy.

Bone scans using Tc-99m diphosphonate were found to become abnormal within 2 weeks after laminectomy in less than half of patients regardless of the extent of the operation. The degree of new uptake equaled that of the sacroiliac joints in only one of 19 patients with a normal preoperative scan. However, the Ga-67 citrate scan usually became abnormal (89%) postoperatively.

Anorectal bleeding vs penile activity. A potential diagnostic problem.

Intrapenile blood pool activity may be a source of artefact in interpreting a gastrointestinal bleeding study employing Tc-99m sulfur colloid or erythrocytes. Proper positioning should avoid a false reading of rectal bleeding.