Caspase-8 activity mediates TNFα production and restricts replication during murine macrophage infection.

is an obligate intracellular bacteria that causes the global zoonotic disease Q Fever. Treatment options for chronic infection are limited, and the development of novel therapeutic strategies requires a greater understanding of how interacts with immune signaling. Cell death responses are known to be manipulated by , but the role of caspase-8, a central regulator of multiple cell death pathways, has not been investigated.

Caspase-8 activity mediates TNFα production and restricts replication during murine macrophage infection.

is an obligate intracellular bacteria which causes the global zoonotic disease Q Fever. Treatment options for infection are limited, and development of novel therapeutic strategies requires a greater understanding of how interacts with immune signaling. Cell death responses are known to be manipulated by , but the role of caspase-8, a central regulator of multiple cell death pathways, has not been investigated.