The impact of correction methods on rare-event meta-analysis.

Meta-analyses have become the gold standard for synthesizing evidence from multiple clinical trials, and they are especially useful when outcomes are rare or adverse since individual trials often lack sufficient power to detect a treatment effect. However, when zero events are observed in one or both treatment arms in a trial, commonly used meta-analysis methods can perform poorly. Continuity corrections (CCs), and numerical adjustments to the data to make computations feasible, have been proposed to ameliorate this issue.