Publications by authors named "Nolan Casey"
Article Synopsis
- The study investigates the roles of BRG1 and BRM ATPase subunits from the SWI/SNF chromatin remodeling complex in the development of endocrine cells, particularly beta cells, which are crucial for insulin production.
- Researchers created genetically modified mice to analyze the impacts of removing BRG1 in endocrine progenitor cells and varying levels of BRM deficiency, assessing metabolic health and pancreatic islet function.
- Findings showed that mice with BRG1 and BRM deficiencies faced severe glucose intolerance and reduced insulin secretion due to diminished islet and hormone-producing cell populations, alongside disrupted gene expression crucial for cell differentiation.
Unlabelled: The transcriptional activity of Pdx1 is modulated by a diverse array of coregulatory factors that govern chromatin accessibility, histone modifications, and nucleosome distribution. We previously identified the Chd4 subunit of the nucleosome remodeling and deacetylase complex as a Pdx1-interacting factor. To identify how loss of Chd4 impacts glucose homeostasis and gene expression programs in β-cells in vivo, we generated an inducible β-cell-specific Chd4 knockout mouse model.
View Article and Find Full Text PDFType 2 diabetes (T2D) is associated with loss of transcription factors (TFs) from a subset of failing β-cells. Among these TFs is Pdx1, which controls the expression of numerous genes involved in maintaining β-cell function and identity. Pdx1 activity is modulated by transcriptional coregulators and has recently been shown, through an unbiased screen, to interact with the Chd4 ATPase subunit of the nucleosome remodeling and deacetylase complex.
View Article and Find Full Text PDF