Publications by authors named "Nolan Carothers"
J Neuroinflammation
May 2024
Article Synopsis
- Epidemiological studies show a strong link between repetitive mild traumatic brain injury (r-mTBI) and increased risk of developing neurodegenerative disorders like chronic traumatic encephalopathy (CTE), with one major feature being the buildup of hyperphosphorylated tau in neurons.
- Research using a mouse model suggests that while r-mTBI doesn't worsen tau astrogliopathy, it does lead to increased phosphorylated tau at the injury site and significant changes in biological functions of tau-bearing astrocytes.
- The findings imply that understanding tau astrogliopathy is crucial for determining how it contributes to brain injury and could help identify potential treatments for r-mTBI and CTE.
