Publications by authors named "Nohara R"

Objective: Human papillomavirus (HPV) vaccination is crucial, particularly for preventing cervical cancer. This study aimed to assess the perceptions of HPV vaccination among healthcare university students in Okayama City, Japan, with the goal of promoting HPV vaccination in the future.

Methods: The study enrolled 168 students (94 male students and 74 female students, median age: 20 (minimum: 18, maximum: 27)) from a healthcare university in Okayama, Japan.

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Article Synopsis
  • A new risk score called the KICKOFF score was developed to predict mortality in patients with acute heart failure (AHF), incorporating physical and social factors alongside clinical data.
  • Two multicenter studies involving over 1,800 patients confirmed that the KICKOFF score accurately predicts all-cause death over a 2-year period, with clear distinctions between low, moderate, and high-risk groups.
  • The KICKOFF score can be applied across different regions in Japan to assist doctors in assessing the risk of mortality in AHF patients, aiding in treatment decisions.
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Background: The Short Physical Performance Battery (SPPB) has been reported to predict clinical outcomes in patients with heart failure (HF). However, whether the discriminative capacity of SPPB score for adverse outcomes varies according to the phenotypes of HF, such as HF with reduced, mid-range, and preserved left-ventricular ejection fraction (HFrEF, HFmrEF, and HFpEF) remains unclear. The aim of this study was to investigate the difference in discriminative capacity of SPPB score for predicting 2-year mortality among phenotypes of HF.

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Pulmonary mucormycosis is an extremely rare disease. It often occurs in immunocompromised patients, such as patients with diabetes and those on long-term steroid use. The prognosis of the disease is poor despite the administration of antifungal agents and removal of the necrotic tissue.

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Article Synopsis
  • The study aims to create and validate a prediction model for all-cause mortality in patients discharged after acute heart failure, addressing a gap in existing clinical scores.
  • A retrospective analysis of the Kitakawachi Clinical Background and Outcome of Heart Failure Registry database was utilized, involving 1,117 patients, with model development using data from 2015-2016 and validation from 2016-2017.
  • The final prediction model included 11 variables, dividing patients into low, moderate, and high-risk groups, showing a notable correlation between predicted and observed mortality rates as confirmed by statistical analysis.
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Background: In Japan, both the prevalence of the elderly and super-elderly and those of acute heart failure (AHF) have been increasing rapidly.

Methods: This registry was a prospective multicenter cohort, which enrolled a total of 1253 patients with AHF. In this study, 1117 patients' follow-up data were available and were categorized into three groups according to age: <75 years old (nonelderly), 75-84 years old (elderly), and ≥ 85 years old (super-elderly).

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This study investigated whether combination therapy (CT) with renin-angiotensin system inhibitors and β-blockers improved endpoints in acute heart failure (AHF). AHF patients were recruited to this prospective multicenter cohort study between April 2015 and August 2017. Patients were divided into 3 categories based on ejection fraction (EF), namely heart failure (HF) with reduced EF (HFrEF), HF with midrange EF (HFmrEF), and HF with preserved EF (HFpEF), and a further into 2 groups according to physical status (those who could walk independently outdoors and those who could not).

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We report photothermal phase separation of aqueous poly(-isopropylacrylamide) (PNIPAM)/1-butanol (BuOH) solutions by focused 1064 nm laser irradiation and subsequent single microparticle formation in the solution. The single microparticle [diameter = ∼10 μm and volume = ∼picoliter (pL)] produced by laser irradiation was optically trapped by the incident 1064 nm laser beam, and this enabled us Raman/fluorescence microspectroscopies of the particle. Raman spectroscopy demonstrated that the particle produced by laser irradiation was composed of PNIPAM and BuOH.

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Home treatment for heart failure (HF) is one of the most important problems in patients after discharge as a secondary preventive measure for rehospitalization for HF. However, there are no detailed studies on gender differences in sociopsychological factors such as living alone for HF rehospitalization among patients with acute HF (AHF).This prospective multicenter cohort study enrolled patients with AHF between April 2015 and August 2017.

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This study aimed to elucidate the epidemiological status of hemoplasma infection and investigate the interaction between Theileria orientalis and hemoplasmas in Japanese Black breeding cows raised in the Kyushu and Okinawa regions. Blood samples were collected from 400 cows from 80 different farms in eight prefectures (five samples per farm and 10 farms per prefecture). Mycoplasma wenyonii (Mw), "Candidatus Mycoplasma haemobos" (CMh), and T.

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Article Synopsis
  • The study investigates the impact of home- and community-based services on elderly patients with acute heart failure (AHF) in Japan, particularly focusing on those enrolled in long-term care insurance (LTCI).
  • During the one-year follow-up, it found that while there was no significant difference in adverse outcomes for super-elderly patients (≥85 years), elderly patients (<85 years) using these services had a significantly lower rate of hospitalization and mortality after discharge.
  • The results suggest that home and community-based services are beneficial in preventing adverse events for elderly patients with AHF, while their impact on super-elderly patients remains unclear.
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Both heart failure (HF) and chronic obstructive pulmonary disease (COPD) are common diseases, but few studies have assessed the relationship between COPD and outcomes in patients with acute HF, especially in relation to age or ejection fraction (EF). The Kitakawachi Clinical Background and Outcome of Heart Failure Registry was a prospective, multicenter, community-based cohort and enrolled a total of 1,102 patients with acute HF between 2015 and 2017 in this study. The primary endpoint was defined as a composite endpoint that included all-cause mortality and hospitalization for HF.

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Background: In Japan, the long-term care insurance (LTCI) system has an important role in helping elderly people, but there have been no clinical studies that have examined the relationship between the LTCI and prognosis for patients with acute heart failure (HF).

Methods and results: This registry was a prospective multicenter cohort, 1,253 patients were enrolled and 965 patients with acute HF aged ≥65 years were comprised the study group. The composite endpoint included all-cause death and hospitalization for HF after discharge.

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Background: There is little evidence regarding the effect of outpatient cardiac rehabilitation (CR) on exercise capacity or the long-term prognosis in patients after coronary artery bypass graft surgery (CABG). This study aimed to determine whether participation in outpatient CR improves exercise capacity and long-term prognosis in post-CABG Japanese patients in a multicenter cohort.

Methods and results: We enrolled 346 post-CABG patients who underwent cardiopulmonary exercise testing during early (2-3 weeks) and late (3-6 months) time points after surgery.

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A man in his 60s visited the emergency department because of epigastric pain and vomiting. Noncontrast helical abdominal CT revealed a lipomatous mass on the right side of the lower esophagus. Caudal slices showed that the mass appeared to displace the gastric antrum causing gastric outlet obstruction.

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Background: Although activities of daily living (ADL) are recognized as being pertinent in averting relevant readmission of heart failure (HF) and mortality, little research has been conducted to assess a correlation between a decline in ADL and outcomes in HF patients.

Methods: The Kitakawachi Clinical Background and Outcome of Heart Failure Registry is a prospective, multicenter, community-based cohort of HF patients. We categorized the patients into four types of ADL: independent outdoor walking, independent indoor walking, indoor walking with assistance, and abasia.

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Introduction: Several reports have described the usefulness of a high-flow nasal cannula (HFNC). However, the physiological mechanisms of this system are unclear. In the current study, various methods were used to investigate the physiological mechanisms of an HFNC in healthy volunteers.

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Background: Primary localized amyloidosis presenting as an isolated mediastinal mass is extremely rare, especially in the thymus. Sclerosing thymoma is also an extremely rare anterior mediastinal tumor, pathologically characterized by extensive sclerotic lesions with hyalinization and calcification. Only 14 cases of sclerosing thymoma and five cases of thymic amyloidosis have been reported to date.

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Individual human models are usually created by direct 3D scanning or deforming a template model according to the measured dimensions. In this paper, we propose a method to estimate all the necessary dimensions (full set) for the human model individualization from a small number of measured dimensions (subset) and human dimension database. For this purpose, we solved multiple regression equation from the dimension database given full set dimensions as the objective variable and subset dimensions as the explanatory variables.

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Background: Social background is important in preventing admission/readmission of heart failure (HF) patients. However, few clinical studies have been conducted to assess the social background of these patients, especially elderly patients.

Methods and results: The Kitakawachi Clinical Background and Outcome of Heart Failure (KICKOFF) Registry is a prospective multicenter community-based cohort of HF patients, established in April 2015.

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Background: Both adaptive servoventilation (ASV) and nocturnal oxygen therapy improve sleep disordered breathing (SDB), but their effects on cardiac parameters have not been compared systematically.

Methods And Results: 43 patients with chronic heart failure (CHF; left ventricular ejection fraction (LVEF) ≤50%) with SDB were randomly assigned to undergo ASV (n=19, apnoea hypopnoea index (AHI)=34.2±12.

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Background: Gliptins should have beneficial effects beyond glycemic control, potentially on the pathophysiology of cardiovascular (CV) diseases, with some basic studies demonstrating this possibility. However, we are yet to answer whether there are any direct CV effects in the clinical setting. We aimed to examine the beneficial effects of sitagliptin in Japanese patients with diabetes and high CV risk for 12 months.

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