A Call for Clarity: A Proposed Toolkit to Integrate Foundational Sciences into Pharmacy Curricula.

The American College of Clinical Pharmacy (ACCP) Pharmacotherapy Didactic Curriculum Toolkit has been used across many schools of pharmacy to guide the depth and breadth of therapeutics coverage, but no counterpart for foundational science coverage in pharmacy education currently exists. Broad topic areas for the foundational sciences are outlined in Appendix 1 of the Accreditation Council for Pharmacy Education (ACPE) standards, but the standards lack specific direction with regard to foundational sciences content needed in the professional pharmacy curriculum. Faculty are therefore challenged to determine the depth and breadth of foundational sciences to meet educational standards within limited curricular space, often resulting in curricular hoarding and overload.

MicroRNA 362-3p Reduces hERG-related Current and Inhibits Breast Cancer Cells Proliferation.

Background/aim: hERG potassium channels enhance tumor invasiveness and breast cancer proliferation. MicroRNA (miRNA) dysregulation during cancer controls gene regulation. The objective of this study was to identify miRNAs that regulate hERG expression in breast cancer.

Effectiveness of a clinical decision support system for reducing the risk of QT interval prolongation in hospitalized patients.

Background: We evaluated the effectiveness of a computer clinical decision support system (CDSS) for reducing the risk of QT interval prolongation in hospitalized patients.

Methods And Results: We evaluated 2400 patients admitted to cardiac care units at an urban academic medical center. A CDSS incorporating a validated risk score for QTc prolongation was developed and implemented using information extracted from patients' electronic medical records.

Development and validation of a risk score to predict QT interval prolongation in hospitalized patients.

Background: Identifying hospitalized patients at risk for QT interval prolongation could lead to interventions to reduce the risk of torsades de pointes. Our objective was to develop and validate a risk score for QT prolongation in hospitalized patients.

Methods And Results: In this study, in a single tertiary care institution, consecutive patients (n=900) admitted to cardiac care units comprised the risk score development group.