Publications by authors named "Noha Eisa"
Community-acquired respiratory viral infections (CARV) significantly impact patients with hematological malignancies (HM), leading to high morbidity and mortality. However, large-scale, real-world data on CARV in these patients is limited. This study analyzed data from the EPICOVIDEHA-EPIFLUEHA registry, focusing on patients with HM diagnosed with CARV during the 2023-2024 autumn-winter season.
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- Polycythemia is common and often related to secondary conditions like high-altitude hypoxia, while a rare condition called polycythemia vera (PV) requires a specialized treatment approach.
- In a study analyzing lab records over three years, out of 208 JAK2 tests, 136 were specifically for polycythemia evaluation, with 22 (16.7%) testing positive for the PV mutation.
- The findings suggest that many patients at high altitude might be incorrectly evaluated for PV based solely on hemoglobin/hematocrit levels; a distinct CBC pattern in PV patients could help streamline evaluations and reduce unnecessary tests.
Article Synopsis
- The COVID-19 pandemic has severely affected individuals with hematological malignancies due to their weakened immune systems, resulting in higher mortality rates and severe outcomes.
- Data from the EPICOVIDEHA registry, which compiles COVID-19 cases from these patients worldwide, was collected from 2020 to 2022, including 8,767 cases from 152 centers across 41 countries.
- Findings show a significant drop in critical infections and overall mortality rates, but hospitalization (especially in ICU) remains a serious risk factor; vaccination is linked to better survival outcomes, highlighting the need for ongoing monitoring and support for these patients.
Background: Natural killer (NK) function defects have been seen in many hematological malignancies, including acute myeloid leukemia (AML). AML is associated with deficient human leukocyte antigen (HLA) expression on leukemia blasts which become targets for killing by NK and natural killer-like T (NKT) cells. However, NK and NKT cells are not effective in killing autologous leukemia blasts, maybe due to number or functional abnormalities.
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- The study aimed to review the findings from multidetector computed tomography (MDCT) in patients with simultaneous lymphoma and other solid tumors.
- It involved a retrospective analysis of 18 patients (8 women and 10 men) diagnosed with both lymphoma and various solid malignancies, confirming all cases through pathological evaluation.
- The results highlighted that MDCT is an effective imaging method for evaluating these conditions, and additional research could enhance understanding and potentially improve treatment strategies for patients with synchronous lymphoma and other malignancies.
MICROtransplant to refractory acute myeloid leukemia in Egyptian population.
Curr Opin Hematol
November 2019
Article Synopsis
- - The review focuses on the Egyptian experience with nonengraftment haploidentical cellular therapy, specifically microtransplantation (MST), for patients with difficult-to-treat acute myeloid leukemia (AML).
- - Recent findings suggest that granulocyte colony-stimulating factor-primed MST could be effective, particularly for patients who are younger, have had fewer than four previous chemotherapy treatments, and haven't previously responded to therapy.
- - Despite its potential, refractory AML remains a tough challenge, indicating that factors like treatment conditioning, stem-cell dosage, and matching must be improved for better outcomes.
Osteolytic bone lesions and hypercalcemia without peripheral blasts B-cell acute lymphoblastic leukemia (B-ALL) are reported in children but rarely seen in adults. Herein, we described two patients with B-ALL presenting with hypercalcemia and symptomatic osteolytic bone lesions. They were treated by standard induction chemotherapy after correction of hypercalcemia with supportive measures.
View Article and Find Full Text PDFSpontaneous regression (SR) of lymphoma is a rare phenomenon. While the precise mechanism of SR remains unknown, apoptosis may be associated with its process. Here, we present a case of a 52-year-old woman was admitted to our hospital with cough and orthopnea for 2 weeks.
View Article and Find Full Text PDFBlastic plasmacytoid dendritic cell neoplasm (BPDCN) is aggressive hematopoietic malignancy derived from the precursors of plasmacytoid dendritic cells. The present study reported a case of a 35-year-old BPDCN patient, who presented with scalp lesions without extracutaneous involvement of the lymph nodes (LNs), peripheral or bone marrow. Histopathological examination of scalp lesion revealed monomorphous diffuse infiltrate of small to medium-sized cells with irregular nuclear contours, pleomorphic nuclei, finely dispersed chromatin, inconspicuous nucleoli and scant amount of cytoplasm.
View Article and Find Full Text PDFMicroangiopathic hemolytic anemia (MAHA) may occur as a paraneoplastic syndrome in some solid tumors, but MAHA accompanied by signet ring cell carcinoma (SRCC) of an unknown origin is very rare. We report a patient who presented with an acute onset of Coombs negative hemolytic anemia and frequent schistocytes in the peripheral blood smear which are typical for MAHA as initial presentation of metastatic SRCC. Our patients fulfilled the criteria of thrombotic thrombocytopenic purpura (TTP) and received the specific treatment for TTP without improvement.
View Article and Find Full Text PDFIntroduction: Data regarding clinical characteristics, therapy, maternal and fetal outcomes of pregnancy-associated acute leukemia are limited.
Patients And Methods: We herein, present the data of 27 pregnancy associated acute leukemia [18 acute myeloid leukemia (AML) and 9 acute lymphatic leukemia (ALL)]. Their data were compared to an age matched group of 75 non-pregnant acute leukemia patients admitted and treated during the same period [53 AML and 22 ALL].