Crotalaria madurensis flavonol glycosides' antibacterial activity against Staphylococcus aureus.

Methicillin-resistant Staphylococcus aureus (MRSA) infections are prevalent in hospitals and often lead to significant health complications. This study aimed to explore the chemical composition of the aerial part of Crotalaria madurensis and evaluate its antioxidant and antibacterial properties. The impact of gamma irradiation on the antibacterial properties of the plant extract and metabolite 1 against MRSA was also examined.

Investigating the involvement of the NLRP3/ASC/caspase-1 and NF-κb/MAPK pathways in the pathogenesis of gouty arthritis: Insights from irradiated and non-irradiated Trifolium alexandrium L. extracts and some metabolites.

Ethnopharmacological Relevance: Trifolium alexandrinum L. (TA), has traditionally been used in folk medicine for its anti-inflammatory properties against hyperuricemia and gout. However, the specific mechanisms of action of TA have not been thoroughly studied.

phytochemicals induce S-phase arrest in A549 lung cancer cell lines via CDK2/cyclin A2 inhibition: gas chromatography-mass spectrometry and molecular docking analyses.

comprises several phytoconstituent classes that are reported to possess anticancer activity; however, studies on the anticancer potentials of the plant are lacking. was extracted using solvents with increasing polarity. cytotoxic activity of extracts was examined against liver (HepG2), lung (A549), prostate (PC3), and bone (MG63) cell lines using MTT assay in comparison to doxorubicin.

Correction to " leaves: Polyphenolic profile, Cytotoxicity, and Antioxidant Evaluation".

[This corrects the article DOI: 10.1021/acsomega.3c04025.

Leaves: Polyphenolic Profile, Cytotoxicity, and Antioxidant Evaluation.

This study aimed to investigate the chemical composition of leaves and evaluate the antioxidant and antitumor effects of the total extract and its major metabolites. Four assays were used to determine the antioxidant activity, including radical scavenging abilities of 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS), radical cation, and ferric-reducing power. Additionally, vincristine was used as a reference medication to examine the anticancer activity on Ehrlich aesthete carcinoma cells (EACC).

leaves, HPLC profile, isolation, and cytotoxicity.

Phytochemicals have played a significant role in the discovery of many clinically anticancer medicines. being famous as an ornamental plant, widely cultivated, and including a wide variety of secondary metabolites this motivated us to explore more about its potential medical applications. In this study, the total methanol extract of leaves (family Apocyanaceae) was sequentially fractionated into hexane, methylene chloride, ethyl acetate, and butanol fractions.