Association between adiponectin single nucleotide polymorphisms and the risk of diabetic polyneuropathy.

Genetic factors play a significant role in the occurrence and clinical course of diabetic peripheral neuropathy (DPN). This research aimed to search the influence of adiponectin single nucleotide polymorphisms (SNPs) on the risk of developing and the severity of DPN in Egyptian patients. Adiponectin SNPs were genotype in 360 participants comprising diabetic sufferers with and without peripheral neuropathy and healthy volunteers via the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) approach.

Burden of multiple sclerosis: impact on the patient, family and society.

Background: Multiple sclerosis (MS) is a chronic autoimmune neurological disease that significantly influences the health-related quality of life of individuals, their families, and society.

Aim: This study aimed to identify the burden of MS on patients' and caregivers' quality of lif E.

Methods: A total of 104 individuals were included consisting of 60 patients with MS (pwMS) diagnosed according to the revised McDonald criteria and 44 caregivers.

Polymorphisms in proinflammatory cytokines genes and susceptibility to Multiple Sclerosis.

Background: Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disorder of the central nervous system (CNS). It is immunologically induced in genetically susceptible individuals. Proinflammatory cytokines play an important role as genetic polymorphisms in their genes might be involved in the susceptibility and pathogenesis of MS.

Evolving relationship between respiratory functions & impairment in sleep and cognition in patients with multiple sclerosis.

Background: The most apparent source of disability in patients with multiple sclerosis (MS) is the physical and mental impact. The pathophysiological mechanisms of cognitive dysfunction are multifactorial although hypoventilation secondary to respiratory dysfunction may contribute to cognitive decline.

Methods: This study was conducted on 146 MS patients with baseline clinical assessments including the Epworth sleepiness scale (ESS) and physical disability was assessed using the Expanded Disability Status Scale (EDSS).

Serum insulin-like growth factor 1 (IGF-1) in multiple sclerosis: relation to cognitive impairment and fatigue.

Background: Multiple sclerosis (MS) is a chronic demyelinating central nervous system (CNS) disease. Changes in insulin growth factor 1 (IGF-1) input to the brain can affect survival of myelin and CNS cells. The study aims to investigate the relation of serum IGF-1 levels with cognitive impairment and fatigue in MS patients.