Publications by authors named "Noguera-Morel L"
Article Synopsis
- * A study analyzing 5 pediatric dermatology books from Brazil and Argentina found that out of 2,471 evaluated photographs, 56% were white, 42% light brown, and there were no representations of dark brown or black skin.
- * This lack of representation in educational materials is problematic, especially since a significant portion of the Brazilian population identifies as Black, underscoring the need to improve diversity in medical resources to enhance healthcare for all skin types.
Article Synopsis
- A 13-year-old boy was diagnosed with hypohidrotic ectodermal dysplasia (HED) linked to a genetic mutation in the ectodysplasin A (EDA) gene.
- He presented with small, white papules on his face, particularly around the nose, forehead, and cheeks.
- Histological analysis showed increased sebaceous lobules in the skin, and there's a suggestion that this might be related to a disruption in the Wnt/β-catenin signaling pathway due to the EDA issue.
Article Synopsis
- The study evaluated characteristics and treatment responses of pediatric patients with pityriasis lichenoides over 43 years, focusing on those under 15 years old.
- A total of 41 patients were analyzed, with the majority having pityriasis lichenoides chronica (PLC), and the highest frequency of cases observed during specific years coinciding with infectious outbreaks.
- Remission occurred in 71.9% of cases, with better outcomes seen in patients who received phototherapy and those whose disease began after age 5.
Article Synopsis
- Inconsistent reporting of outcomes in rosacea clinical trials is hindering accurate data analysis and meta-analyses, highlighting the need for standardized outcome measures.
- A core outcome set (COS) was developed through systematic literature reviews and a Delphi process, involving feedback from physicians and patients to identify essential outcomes in rosacea trials.
- The final COS includes 8 key domains, such as skin symptoms and patient satisfaction, which aim to enhance the comparability and relevance of future rosacea research and interventions.
Article Synopsis
- Lymphomatoid papulosis (LyP) is a rare skin disorder affecting T-cells, and there's limited information about its impact on children.
- A study analyzed data from 87 pediatric patients diagnosed with LyP over a 24-year period, noting that most cases were initially misdiagnosed and the average age at onset was 7 years.
- The prognosis appears positive, with a 100% overall survival rate, although 10% of patients had associated blood cancers, indicating a significantly higher risk of malignancy compared to the general youth population.
A healthy 2-year-old girl presented with multiple asymptomatic subcutaneous nodules on both legs. Histologically demonstrated calcium deposition within the dermis and subcutaneous tissue consistent with calcinosis cutis. Laboratory abnormalities, underlying genetic conditions, and potential triggering factors were ruled out.
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- The study focuses on the diagnosis of Neurofibromatosis type 1 (NF1) in children, highlighting that it's often delayed without a family history, and aims to compare skin manifestations in NF1 patients to those in the general population.
- Researchers conducted a case-control study with 108 NF1 patients and 137 healthy controls, finding significantly higher prevalence rates of nevus anemicus (NA) and juvenile xanthogranulomas (JXG) in NF1 patients.
- The results suggest that NA and JXG should be considered for inclusion in the diagnostic criteria for NF1, especially in young children, due to their strong association with the condition.
Article Synopsis
- The study investigates the prevalence and characteristics of skin manifestations in children with Neurofibromatosis type 1 (NF1), particularly comparing them to a control group of healthy children.
- Research included 108 NF1 patients and 137 healthy controls, revealing significantly higher occurrences of nevus anemicus and juvenile xanthogranulomas in NF1 patients.
- The findings suggest that these skin manifestations are important for diagnosing NF1 in early childhood and may warrant their inclusion in the official diagnostic criteria.
A 4-year-old girl presented with congenital patches of scalp alopecia, which on physical examination, was consistent with blaschkolinear alopecic patches with mild epidermal atrophy. Similar atrophic hypopigmented patches were seen on the trunk and proximal extremities. With the clinical suspicion of Conradi-Hünermann-Happle syndrome, genetic testing was performed and revealed a mutation in the EBP gene.
View Article and Find Full Text PDFRosacea is a chronic inflammatory condition that affects the skin and the eyes. The pathogenesis of rosacea is complex and includes the interaction between genetic and environmental factors, dysregulation of the innate immune system, neurovascular modifications and the interaction with skin commensals. Clinical manifestations in children include the telangiectatic form, papulopustular rosacea, ocular rosacea, periorificial dermatitis, granulomatous rosacea and idiopathic facial aseptic granuloma.
View Article and Find Full Text PDFA growing number of skin lesions during the COVID-19 pandemic are being recognized. Acral ischemic lesions identical to chilblains are most typical in children and young adults. We report an infant girl, aged 1 month and 29 days, with a peculiar reticulated purpuric eruption on her soles, with positive immunohistochemistry for SARS-CoV-2 in the endothelia of dermal blood vessels.
View Article and Find Full Text PDFDermoscopy features of COVID-19-related chilblains in children and adolescents.
J Eur Acad Dermatol Venereol
December 2020
Background: Chilblains ('COVID toes') are being seen with increasing frequency in children and young adults during the COVID-19 pandemic. Detailed histopathological descriptions of COVID-19 chilblains have not been reported, and causality of SARS-CoV-2 has not yet been established.
Objectives: To describe the histopathological features of COVID-19 chilblains and to explore the presence of SARS-CoV-2 in the tissue.
During examination of cases of chilblains in children and adolescents, we identified four patients who also showed skin lesions similar to erythema multiforme (EM). They had no other known triggers for EM. One of them had a positive PCR for SARS-CoV-2, while the other three were negative.
View Article and Find Full Text PDFBackground: Different skin manifestations of COVID-19 are being reported. Acral lesions on the hands and feet, closely resembling chilblains, have been recognized during the peak incidence of the COVID-19 pandemic.
Material And Methods: A retrospective review of 22 children and adolescents with chilblain-like lesions seen over a short period of time in the Emergency Department of a children's hospital during the peak incidence of COVID-19 in Madrid, Spain.
Article Synopsis
- - The term mid-face toddler excoriation syndrome (MiTES) refers to a rare condition in infants, marked by self-inflicted skin lesions, primarily on the face.
- - MiTES is thought to be a milder form of hereditary sensory-autonomic neuropathy (HSAN) type VIII, which affects pain sensation.
- - An 8-year-old boy with this syndrome exhibited self-inflicted facial lesions and an unusually high pain threshold, prompting a review of its diagnosis and management.
A Spitz nevus is a melanocytic neoplasm of epithelioid and/or spindle cells that usually appears in childhood. These lesions are by nature benign, but their features can sometimes make them difficult to distinguish from melanomas. Spitzoid melanocytic lesions have been grouped into 3 types in recent decades: Spitz nevi, atypical Spitz tumors, and spitzoid melanomas.
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- Papillary hemangioma (PH) is a rare, non-cancerous tumor primarily found on the scalp and face, mostly in adults.
- The text discusses a unique case of PH occurring in a child.
- It also highlights specific sonographic features that could help in diagnosing this condition.