Associations between autoimmune conditions and hepatobiliary cancer risk among elderly US adults.

Growing evidence suggests that people with autoimmune conditions may be at increased risk of hepatobiliary tumors. In the present study, we evaluated associations between autoimmune conditions and hepatobiliary cancers among adults aged ≥66 in the United States. We used Surveillance, Epidemiology, and End Results (SEER)-Medicare data (1992-2013) to conduct a population-based, case-control study.

Breed composition does not influence the performance of Holstein-Gyr crossbred as oocyte donors for OPU/IVP.

Holstein-Gyr crossbred cattle are strategic for dairy systems in tropical countries, since they combine milk yield genetics with adaptability to tropical climate. However, Holstein () and Gyr () breeds present remarkable differences regarding reproductive physiology. Brazil stands out as the world's largest user of embryo production (IVP) in bovine, and the use of this technique is increasing in dairy systems.

Educational technology for people living with HIV: validation study.

Objective: to validate an educational technology to support the action of health professionals with people living with HIV.

Method: methodological study with data collection using a four-point Likert scale for evaluation by eleven judges and 51 people living with HIV. The data were tabulated, processed, and analyzed by inferential and descriptive statistics, Cronbach's alpha test, and Kruskal-Wallis for reliability and internal consistency analyses.

Contribution of academic tutoring for the teaching-learning process in Nursing undergraduate studies.

Objective: to analyze the perceptions of professors and students on academic tutoring.

Method: descriptive study with a qualitative approach, carried out at the Magalhães Barata School of Nursing, State University of Pará, Brazil. Twenty-seven professors and 32 students participated in the study.

Assessing gastric residual volume: a description of nurses' clinical practice.

Objective: To analyze the differences in nurses' clinical practice for assessing residual gastric volume and identifying the theoretical framework which supports their practice.

Method: A cross-sectional study carried out by sending an online questionnaire by e-mail to nurses registered at the Regional Nursing Council of the State of São Paulo.

Results: This study included 598 nursing professionals, with 484 only providing care to adults and 114 exclusively to children.

Overview of Curricula About Pain in Physical Therapist Education Programs in Brazil: A Faculty Survey.

Background: Educating health professionals about pain (pain education) during undergraduate studies may be an important step in changing ineffective pain management practices.

Objective: The objective of this study was to assess the extent of pain education in current accredited physical therapist education programs in Brazil.

Design: This study was designed as a cross-sectional survey study.

Saw marks in bones: A study of "secondary features" of false start lesions.

In this experiment, 170 experimental false starts on human (120 lesions) and pig bones (50 lesions) were analyzed under stereomicroscope. The goal was to evaluate the potential of three "secondary" features (patterns of striae on the kerf floor, blade drift and bone islands) to diagnose saw class and saw set. We also assessed the performance of each of these features in ambiguous cases observed in a previous study, based on three main characters (minimum width of the kerf, shape of the kerf walls, and shape of the kerf profile).

Patients with Impaired Descending Nociceptive Inhibitory System Present Altered Cardiac Vagal Control at Rest.

Background: Patients with chronic musculoskeletal pain have a higher chance of presenting impairment in cardiovascular autonomic modulation, which may have implications for cardiovascular events. The autonomic nervous system plays an important role in pain modulation. However, it is unclear whether patients with inefficient descending nociceptive inhibition have poorer cardiovascular autonomic modulation.

Genetic variation in Wnt/β-catenin and ER signalling pathways in female and male elite dancers and its associations with low bone mineral density: a cross-section and longitudinal study.

Unlabelled: The association of genetic polymorphisms with low bone mineral density in elite athletes have not been considered previously. The present study found that bone mass phenotypes in elite and pre-elite dancers are related to genetic variants at the Wnt/β-catenin and ER pathways.

Introduction: Some athletes (e.

[Not Available].

Popliteal artery aneurysms account for 70% of peripheral aneurysms and must be treated surgically. The results of endovascular treatment are controversial. The objective of this study is to conduct a literature review on comparisons between open surgery and endovascular treatment for popliteal artery aneurysms.

Disturbance in Na regulation in cells rich in mitochondria isolated from gills of the yellow clam Mesodesma mactroides exposed to copper under different osmotic conditions.

Cells rich in mitochondria were isolated from gills of the seawater clam Mesodesma mactroides, incubated in isosmotic saline solution (840 mOsmol/kg HO), and exposed (3 h) to environmentally realistic Cu concentrations (nominally: 0, 5, 9 and 20 μg/L). In cells exposed to 20 μg Cu/L, Cu accumulation, Na content reduction and carbonic anhydrase (CA) activity inhibition were observed, without significant changes in cell viability and Na,K-ATPase (NKA) activity. In the absence of Cu, cell viability and Cu content were reduced in hyposmotic media respect with the control, without changes in Na content and enzyme (CA and NKA) activities.

Trial Protocol: Cognitive functional therapy compared with combined manual therapy and motor control exercise for people with non-specific chronic low back pain: protocol for a randomised, controlled trial.

Introduction: Chronic low back pain is a public health problem, and there is strong evidence that it is associated with a complex interaction of biopsychosocial factors. Cognitive functional therapy is an intervention that deals with potentially modifiable multidimensional aspects of pain (eg, provocative cognitive, movement and lifestyle behaviours). There is evidence (from a single randomised, controlled trial) that cognitive functional therapy is better than combined manual therapy and motor control exercise.

Types of non-psychotic mental disorders in adult women who suffered intimate partner violence: an integrative review.

Objective: Identifying the types of non-psychotic mental disorders in adult women who suffered intimate partner violence in the literature.

Method: An integrative review carried out in the MEDLINE, CINAHL, LILACS, Web of Science and SCOPUS databases.

Results: We selected 19 articles published in international journals in English, with a predominance of cross-sectional study studies (78.

Penile cancer in Maranhão, Northeast Brazil: the highest incidence globally?

Background: The objectives of this study were to determine the minimum incidence of penile cancer in the poorest Brazilian state, and to describe the epidemiologic and clinical characteristics of patients diagnosed with the disease.

Methods: A retrospective study of 392 patients diagnosed with penile cancer in the three most important referral center in the state was conducted during 2004-2014.

Results: The age-standardized incidence was 6.

Cigarette smoke directly impairs skeletal muscle function through capillary regression and altered myofibre calcium kinetics in mice.

Key Points: Cigarette smoke components directly alter muscle fatigue resistance and intracellular muscle fibre Ca handling independent of a change in lung structure. Changes in muscle vascular structure are associated with a depletion of satellite cells. Sarcoplasmic reticulum Ca uptake is substantially impaired in myofibres during fatiguing contractions in mice treated with cigarette smoke extract.

Comparative Evaluation of Cell Viability Immediately After Osteotomy for Implants With Drills and Piezosurgery: Immunohistochemistry Analysis.

Objective: To evaluate the effect of reusing drills and piezosurgery tips during implant osteotomy on immediate bone cell viability through immunohistochemical analysis.

Materials And Methods: Six male rabbits were divided into 2 groups and then divided into 5 subgroups-correspond to drills and tips used 10, 20, 30, 40, and 50 times, respectively. All animals received 10 osteotomies in each tibia, by use of the classic drilling procedure in one group (G1) and the piezosurgery device in the other group (G2).

Molybdenum(0) tricarbonyl and tetracarbonyl complexes with a cationic pyrazolylpyridine ligand: synthesis, crystal structures and catalytic performance in olefin epoxidation.

The synthesis of molybdenum(0) tricarbonyl and tetracarbonyl complexes of the form [Mo(CO)(ptapzpy)Br] (1) and -[Mo(CO)(ptapzpy)]Br (2) is reported, where ptapzpy = 2-(1-propyltrimethylammonium-3-pyrazolyl)pyridine. Preparation of these derivatives was accomplished either through thermal replacement of CO in Mo(CO) (for 1) or substitution under milder conditions of piperidine ligands in the precursor -[Mo(CO)(pip)] (for 2). The crystal structures of the ligand [ptapzpy]Br and complexes 1 and 2 were determined.

Association between pain drawing and psychological factors in musculoskeletal chronic pain: A systematic review.

Background: It has been speculated that there is an association between pain area and psychological factors in chronic musculoskeletal pain conditions; however, this relation is not well established.

Purpose: To investigate the association between pain distribution and psychological factors in chronic musculoskeletal pain conditions.

Study Design: Systematic review.

Phosphine Exposure Among Emergency Responders - Amarillo, Texas, January 2017.

Phosphine is a highly toxic gas that forms when aluminum phosphide, a restricted-use pesticide* typically used in agricultural settings, reacts with water. Acute exposure can lead to a wide range of respiratory, cardiovascular, and gastrointestinal symptoms, and can be fatal (1). On January 2, 2017, the Texas Department of State Health Services (DSHS) was notified by the Texas Panhandle Poison Center of an acute phosphine exposure incident in Amarillo, Texas.

Optimizing the treatment of metastatic castration-resistant prostate cancer: a Latin America perspective.

Prostate cancer is a significant burden and cause of mortality in Latin America. This article reviews the treatment options for patients with metastatic castration-resistant prostate cancer (mCRPC) and provides consensus recommendations to assist Latin American prostate cancer specialists with clinical decision making. A multidisciplinary expert panel from Latin America reviewed the available data and their individual experience to develop clinical consensus opinions for the use of life-prolonging agents in mCRPC, with consideration given to factors influencing patient selection and treatment monitoring.

New Trauma and Injury Severity Score (TRISS) adjustments for survival prediction.

Background: The objective of this study is to propose three new adjustments to the Trauma and Injury Severity Score (TRISS) equation and compare their performances with the original TRISS as well as this index with coefficients adjusted for the study population.

Methods: This multicenter, retrospective study evaluated trauma victims admitted to two hospitals in São Paulo-Brazil and San Diego-EUA between January 1st, 2006, and December 31st, 2010. The proposed models included a New Trauma and Injury Severity Score (NTRISS)-like model that included Best Motor Response (BMR), systolic blood pressure (SBP), New Injury Severity Score (NISS), and age variables; a TRISS peripheral oxygen saturation (SpO) model that included Glasgow Coma Scale (GCS), SBP, SpO, Injury Severity Score, and age variables; and a NTRISS-like SpO model that included BMR, SBP, SpO, NISS, and age variables.

Access to Street Markets and Consumption of Fruits and Vegetables by Adolescents Living in São Paulo, Brazil.

Food environment and income act as determinants of diet, and consequently, of the consumption of fruits and vegetables. The objective of this study is to investigate the association between fruit and vegetable consumption, income, and street market density in adolescents living in São Paulo, Brazil. Data from 521 adolescents (12 to 19 years) participating in the 2015 Health Survey of São Paulo were used.

miR-145 Antagonizes SNAI1-Mediated Stemness and Radiation Resistance in Colorectal Cancer.

Epithelial-to-mesenchymal transition (EMT) has been closely linked with therapy resistance and cancer stem cells (CSCs). However, EMT pathways have proven challenging to therapeutically target. MicroRNA 145 (miR-145) targets multiple stem cell transcription factors and its expression is inversely correlated with EMT.

Physiological effects of marine natural organic matter and metals in early life stages of the North Pacific native marine mussel Mytilus trossulus; a comparison with the invasive Mytilus galloprovincialis.

The role of seawater NOM in reducing metal toxicity for marine organisms is not well understood. We investigated the effects of five different marine NOMs (two autochthonous, one allochthonous, two of mixed origin, at 8 mg C/L), three metals (6 μg Cu/L; 20 μg Pb/L; 25 μg Zn/L), and combinations between them, to early life stages of Mytilus trossulus (a North Pacific native) in 48-h tests. Endpoints were whole body Ca+Mg-ATPase activity, carbonic anhydrase (CA) activity and lipid peroxidation.