Publications by authors named "Nogue D"
Article Synopsis
- Scientists studied how a special gas called xenon helps protect brain cells that produce a chemical called dopamine from damage.
- They found that the more xenon they used, the better it worked, and that other noble gases like helium and neon didn’t help at all.
- Their research suggests that xenon could be important for treating Parkinson's disease, where these dopamine-producing cells are at risk of being harmed.
Despite its low chemical reactivity, the noble gas xenon possesses a remarkable spectrum of biological effects. In particular, xenon is a strong neuroprotectant in preclinical models of hypoxic-ischemic brain injury. In this study, we wished to determine whether xenon retained its neuroprotective potential in experimental settings that model the progressive loss of midbrain dopamine (DA) neurons in Parkinson's disease.
View Article and Find Full Text PDFXenon-mediated neuroprotection in response to sustained, low-level excitotoxic stress.
Cell Death Discov
August 2016
Noble gases such as xenon and argon have been reported to provide neuroprotection against acute brain ischemic/anoxic injuries. Herein, we wished to evaluate the protective potential of these two gases under conditions relevant to the pathogenesis of chronic neurodegenerative disorders. For that, we established cultures of neurons typically affected in Alzheimer's disease (AD) pathology, that is, cortical neurons and basal forebrain cholinergic neurons and exposed them to L-trans-pyrrolidine-2,4-dicarboxylic acid (PDC) to generate sustained, low-level excitotoxic stress.
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