Publications by authors named "Nofar Kimchi"
Article Synopsis
- - The study measured protein levels in 986 individuals to predict the severity of COVID-19, using both protein data and clinical risk factors to build predictive models.
- - A baseline model using age and sex achieved a prediction accuracy of 65%, but incorporating 92 specific proteins improved this accuracy to 88% in the initial group and maintained 86% in a separate test group.
- - Findings indicate that early-stage protein measurements can effectively predict COVID-19 severity, highlighting the need for further research to integrate these measurements into clinical practice.
Article Synopsis
- This study investigates how severe COVID-19 affects levels of immune-related proteins and their differences based on sex.
- Researchers analyzed data from 580 patients by measuring 147 immune proteins during the first 14 days of infection to uncover significant differences between severe cases and controls.
- The findings revealed that 69 proteins differed significantly between groups, and some proteins showed variations between sexes, which could help explain the differing outcomes in COVID-19 severity based on gender.
Background: Increased vitamin D levels, as reflected by 25-hydroxy vitamin D (25OHD) measurements, have been proposed to protect against COVID-19 based on in vitro, observational, and ecological studies. However, vitamin D levels are associated with many confounding variables, and thus associations described to date may not be causal. Vitamin D Mendelian randomization (MR) studies have provided results that are concordant with large-scale vitamin D randomized trials.
View Article and Find Full Text PDFTo identify circulating proteins influencing Coronavirus Disease 2019 (COVID-19) susceptibility and severity, we undertook a two-sample Mendelian randomization (MR) study, rapidly scanning hundreds of circulating proteins while reducing bias due to reverse causation and confounding. In up to 14,134 cases and 1.2 million controls, we found that an s.
View Article and Find Full Text PDFThe allergic eye: recommendations about pharmacotherapy and recent therapeutic agents.
Curr Opin Allergy Clin Immunol
August 2020
Purpose Of Review: Ocular allergies affect an estimated 40% of the population, 98% of which are because of allergic conjunctivitis. With the current advent of both repurposed drugs for ocular allergies, as well as novel drugs and methods of administration, there is a need for an updated review of current available medications. A clear characterization of each treatment will ultimately allow treating physicians to restore patients' quality of life and decrease burden of disease.
View Article and Find Full Text PDFData on anaphylaxis cases in pre-hospital settings is limited. As part of the Cross Canada Anaphylaxis Registry (C-CARE), we assessed anaphylaxis cases managed by paramedics in Outaouais, Quebec. A software program was developed to prospectively record demographic and clinical characteristics as well as management of cases meeting the definition of the anaphylaxis.
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