Publications by authors named "Noemie Louis-Joseph"
Article Synopsis
- Abnormal levels of CDKN1A/p21 can lead to opposite effects in cells, either causing rapid growth in p53-deficient cancer cells or slowing growth in hematopoietic stem cells, potentially leading to bone marrow failure (BMF).
- In Fanconi anemia (FA), p21 is overexpressed due to both p53 and the transcription factor microphthalmia (MITF), contributing to the disease's symptoms, but the exact mechanisms remain unclear.
- The study finds that elevated p21 in FA cells is linked to chromatin changes and increased genetic instability, and that reactive oxygen species (ROS) are crucial for this overexpression, suggesting a complex interaction that worsens cell replication issues.
