Publications by authors named "Noelle Nieskens"
Article Synopsis
- Trichomonas vaginalis causes trichomoniasis, a widespread STD that affects over a hundred million people, and resistance to common treatments like metronidazole is increasing.
- The study explored using Tritrichomonas foetus, a related parasite, as a better animal model for testing new treatments since it caused reliable infections in mice, unlike T. vaginalis.
- Findings showed that while some drugs had similar effectiveness on both parasites, proteasome inhibitors were less effective on T. foetus, suggesting the need for targeted drug development and further understanding of genetic differences between the two organisms.
The protozoan pathogen Giardia lamblia is an important worldwide cause of diarrheal disease and malabsorption. Infection is managed with antimicrobials, although drug resistance and treatment failures are a clinical challenge. Prior infection provides significant protection, yet a human vaccine has not been realized.
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