Publications by authors named "Noelle Huskey-Mullin"
Article Synopsis
- The study investigates how certain human CD8 T cells, known as effector memory T cells, can be recruited to tumors through a receptor called CMKLR1 that binds to the molecule chemerin.
- It was found that in a prostate tumor mouse model, low levels of chemerin in the tumor microenvironment correlate with fewer CD8 T cells, while increasing chemerin leads to more T cell accumulation.
- The findings suggest that targeting the chemerin and CMKLR1 pathway may enhance immunotherapy by promoting the recruitment of specialized CD8 T cells that behave like natural killer (NK) cells into tumors.
