Naltrexone in alcohol dependence: a randomised controlled trial of effectiveness in a standard clinical setting.

Objectives: To determine whether naltrexone is beneficial in the treatment of alcohol dependence in the absence of obligatory psychosocial intervention.

Design: Multicentre, randomised, double-blind, placebo-controlled trial.

Setting: Hospital-based drug and alcohol clinics, 18 March 1998 - 22 October 1999.