Publications by authors named "Noelie Bere Henry"
Seasonal Malaria Chemoprevention Implementation: Effect on Malaria Incidence and Immunity in a Context of Expansion of Resistant Genotypes with Potential Reduction of the Effectiveness in Sub-Saharan Africa.
Séni Nikiema Issiaka Soulama Salif Sombié André-Marie Tchouatieu Samuel Sindie Sermé Noëlie Béré Henry
Infect Drug Resist
August 2022
Article Synopsis
- Seasonal Malaria Chemoprevention (SMC), which uses a combination of amodiaquine and sulfadoxine-pyrimethamine, is endorsed by the WHO as a method to reduce malaria cases in areas with intense seasonal transmission, especially among children under 5.
- Despite its potential benefits, there are ongoing debates around its effectiveness due to issues like developing malaria-specific immunity, growing resistance to antimalarial drugs, and limited delivery to children.
- The review highlights the need to evaluate the SMC's impact on malaria morbidity and resistance, and aims to identify factors affecting the success of the strategy to enhance malaria control in affected regions.
Article Synopsis
- Malaria infection causes different immune responses in children, largely due to metabolic changes that are not fully understood.
- In a study of children from two ethnic groups in West Africa, researchers discovered specific metabolites associated with malaria that influence the immune system.
- The findings highlight how steroids produced during infection can suppress immune function, pointing to new possibilities for malaria treatment strategies.
While significant advances have been made in understanding Plasmodium falciparum gametocyte biology and its relationship with malaria parasite transmission, the gametocyte sex ratio contribution to this process still remains a relevant research question. The present review discusses the biology of sex determination in P. falciparum, the underlying host and parasite factors, the sex specific susceptibility to drugs, the effect of sex ratio dynamics on malaria parasite transmission and the development of gametocyte sex specific diagnosis tools.
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- During the peak malaria transmission season in a rural area of Burkina Faso, a study analyzed the haematological profiles of 414 children, where 222 were asymptomatic carriers of Plasmodium, the malaria parasite.
- The study found that asymptomatic infected children had significantly lower levels of haemoglobin, lymphocytes, platelets, and red blood cells compared to uninfected controls, while having a higher monocyte count.
- The findings suggest that asymptomatic malaria infections can alter important blood parameters, highlighting the need for careful interpretation in clinical evaluations and vaccine trials for children in malaria-endemic regions.