Publications by authors named "Noelia Perez-Munoz"

Article Synopsis
  • B-cell epidermotropism is a rare occurrence in skin lymphomas, typically seen in systemic lymphomas like splenic marginal zone lymphoma.
  • This type of lymphoma can present with skin symptoms before other signs, such as an enlarged spleen, and may involve bone marrow or blood.
  • The case discussed highlights the importance for clinicians to recognize this feature, as it may indicate further disease spread and necessitate more thorough initial staging.
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Tumour budding (TB) correlates with increased local invasion in various neoplasms. Certain basal cell carcinomas (BCCs) exhibit local aggressiveness. Detecting adverse prognostic factors in partial biopsies could aid in identifying cases with heightened local risk.

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Article Synopsis
  • - This article is the second part of a series focused on the histopathological features and differential diagnoses of cystic and pseudocystic structures found in skin biopsies.
  • - It specifically discusses various types of cysts, including ciliated cutaneous cysts, branchial cysts, Bartholin's cysts, thymic cysts, and more.
  • - Additionally, the article covers related structures like mucoceles, ganglion cysts, and myxoid pseudocysts found in the ear and fingers.
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Article Synopsis
  • Pilomatrixoma is a rare but benign tumor that arises from the hair follicle structure, primarily affecting the hair matrix.
  • A case involving an elderly man with a nodular lesion on his forearm highlights the need for accurate diagnosis, initially confusing it with both benign and malignant conditions.
  • The study emphasizes the value of diagnostic tools like dermoscopy and high-frequency ultrasonography, while also discussing rarer variants of pilomatrixoma to enhance clinical awareness and improve diagnosis.
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Cystic structures represent one of the most common findings in dermatopathology. These encompass both cystic tumors and pseudocysts resulting from the accumulation of certain substances, such as mucin. In a two-part series (of which this is the first part), we have reviewed the principal types of cysts and pseudocysts that may be observed in cutaneous biopsies, examining their histopathological features and primary differential diagnoses.

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Invisible dermatosis is a concept that can be applied either to clinical or histopathological findings. We will focus on the dermatopathological aspect of this invisible dermatosis that can be seen as dermatosis with subtle histopathological findings that are mandatory to known to stablish the diagnosis. With a proper approach facing in depth the different skin layers from stratum corneum to subcutaneous tissue combined with some especial stains, special investigations and mostly a proper clinicopathological correlation, the problem of missing out a diagnosis can be decreased.

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Article Synopsis
  • Reactions to tattoos can mimic skin conditions or tumors, making histopathological analysis essential for accurate diagnosis and treatment direction.
  • The study analyzed biopsies from 1992 to 2019 from several hospitals in Spain and Switzerland, focusing on different types of tattoos and their associated reactions.
  • Out of 477 biopsies, 230 met the criteria for inclusion, with the findings indicating a range of inflammatory responses and various age groups affected, highlighting the importance of understanding tattoo reactions in clinical practice.
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Adenoma of the nipple is a very uncommon benign neoplasm of lactiferous ducts. Its clinical presentation is variable and it can be easily misdiagnosed as a malignancy such as mammary Paget disease or breast intraductal carcinoma. Although dermoscopy and imaging tests such as ultrasonography or mammography can be of help, histological examination is mandatory to confirm the diagnosis.

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Angioleiomyomas are benign neoplasms, which usually present as solitary, slow-growing nodules on the skin of lower extremities, but acral location on the hands or feet is unusual. Yet, microscopically, they may show many histopathological variants, focal calcification is uncommon. Extensive calcification masquerading the real nature of the tumor has been rarely reported, the term acral calcified leiomyoma having been proposed for this entity.

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Lipomatous metaplasia of the upper dermis is a rare phenomenon scarcely described in the literature which has always been identified in the context of inflammatory or neoplastic processes. Microscopically, it should be distinguished from pseudolipomatosis cutis, dermal lipoma, nevus lipomatosus, and focal dermal hypoplasia (Goltz syndrome). This is the first report of the histologic and ultrasound evaluation of a patient with extensive involvement and the description of the coincidental finding of an anomalous nonseptate subcutaneous tissue.

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Background: Cystic lesions are common in the daily practice of dermatologists and dermatopathologists, and in most cases, a straightforward diagnosis can be done. Yet, some variants and situations may cause diagnostic problems or carry prognostic and/or systemic implications.

Objective: To review the histopathological features of the most frequent cystic lesions, either true cysts or pseudocysts, and provide some clues and pitfalls to bear in mind for troublesome situations such as solid-cystic tumors; uncommon variants; incidental findings; artifactual, reactive, or infectious cavities; cysts as a warning of systemic and hereditary diseases; and malignant cystic tumors, either primary or metastatic.

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Cutaneous nerve hyperplasia is characterized by the presence of increased and hypertrophic myelinated and unmyelinated nerve fibers in the dermis. We report a case of periadnexal nerve hyperplasia as an asymptomatic and infrequent reactive histopathological change, with no associated risk of malignancy that can be seen in scars, in patients with no syndromic stigmata.

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A 75-year-old man presented to the dermatology clinic with an asymptomatic lesion on his right plantar surface. The lesion had progressively grown for two months. Physical examination revealed an erythematous and slightly scaly nodule measuring 10x10 mm.

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We herein report two cases of eosinophilic annular erythema in adults, which is rare. In both patients, lesions developed rapidly in few days and were located mainly on the trunk, buttocks, and extremities. Diagnosis was histopathological, with typical features including acute dermal inflammatory infiltrate with abundant eosinophils.

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