Publications by authors named "Noelia G Barrio"
The aim of this study was to analyze whether the coronavirus disease 2019 (COVID-19) vaccine reduces mortality in patients with moderate or severe COVID-19 disease requiring oxygen therapy. A retrospective cohort study, with data from 148 hospitals in both Spain (111 hospitals) and Argentina (37 hospitals), was conducted. We evaluated hospitalized patients for COVID-19 older than 18 years with oxygen requirements.
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- The study analyzed data from over 689,000 hospitalized COVID-19 patients across 52 countries from January 2020 to January 2022, examining demographic characteristics, symptoms, co-morbidities, and treatment outcomes.
- Key findings indicate that older age and male sex significantly increased the risk of death, with the hazard ratio for age being 1.49 per 10 years, while the case-fatality ratio averaged 21.5% and varied by country.
- The research highlights that age is the primary risk factor for mortality, with significant associations found for co-morbidities, smoking, and obesity, providing valuable insights for clinical strategies to address COVID-19.
Given the growing number of prediction algorithms developed to predict COVID-19 mortality, we evaluated the transportability of a mortality prediction algorithm using a multi-national network of healthcare systems. We predicted COVID-19 mortality using baseline commonly measured laboratory values and standard demographic and clinical covariates across healthcare systems, countries, and continents. Specifically, we trained a Cox regression model with nine measured laboratory test values, standard demographics at admission, and comorbidity burden pre-admission.
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