Nasal nitric oxide in children: a novel measurement technique and normal values.

Objectives: To develop and standardize a technique for measuring nasal nitric oxide (NO) output in children and to determine normal values in this population.

Study Design: Prospective study evaluating a new technique for measuring nasal nitric oxide in a cohort of normal patients and a cohort of patients with nasal disease.

Methods: Nasal NO was measured using an aspiration technique, aspirating room air through the nasal cavities by means of a Teflon nozzle placed in one nasal vestibule while maintaining velopharyngeal closure using a party "blow-out" toyRESULTS Nasal NO measurements were performed in 45 children (mean age, 11.