Publications by authors named "Noel Lowry"
Background: Few prospective studies have systematically evaluated the extent of recovery from incident acquired demyelinating syndromes (ADS) of the central nervous system in children.
Methods: In a national cohort study of pediatric ADS, severity of the incident attack and extent of recovery by 12 months were evaluated. Annual evaluations were used to determine current diagnoses (monophasic ADS or multiple sclerosis [MS]) and new deficits.
Article Synopsis
- The study aimed to explore whether specific genetic (HLA-DRB1*15), viral (previous Epstein-Barr virus infection), and environmental (vitamin D insufficiency) factors, alongside MRI findings and CSF analysis, contribute to the risk of developing multiple sclerosis in children following CNS demyelination.
- Researchers analyzed data from 332 children experiencing CNS demyelination across Canada, finding that 21% were eventually diagnosed with multiple sclerosis, with significant associations identified for certain risk factors, although no interactions between these factors were found.
- Notably, the presence of brain lesions on MRI and oligoclonal bands in CSF were strongly linked to multiple sclerosis, denoting established disease, indicating that
The recognition of epileptic seizures in newborns is challenging as neonates exhibit a variety of paroxysmal motor phenomena, some epileptic but others not. The distinction, frequently requiring video-EEG monitoring, is crucial for management. Causes are often multi-factorial, specific to country/region, and change over time.
View Article and Find Full Text PDFA female heterozygous for a novel, disease causing, missense mutation in the X-linked cerebral creatine transporter (SLC6A8) gene (c.1067G>T, p.Gly356Val) presented with intractable epilepsy, mild intellectual disability and moderately reduced cerebral creatine levels.
View Article and Find Full Text PDFBackground: Video-electroencephalography (VEEG) telemetry is the simultaneous recording of ictal and interictal EEG pattern and paroxysmal behavior to investigate the nature of paroxysmal events.
Methods: This is a prospective study performed to asses the safety and yield of early discontinuation of antiepileptic drugs (AEDs) in the telemetry unit. Over a 2.
The newborn infant is prone to clinical motor phenomena that are not epileptic in nature. These include tremors, jitteriness, various forms of myoclonus and brainstem release phenomena. They are frequently misdiagnosed as seizures, resulting in unnecessary investigations and treatment with anticonvulsants, which have potentially harmful side effects.
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