Socio-spatial inequalities in presence of primary care physicians and patients' ability to register: A simulated-patient survey in the Paris Region.

Objectives: We studied the socio-spatial inequalities of three types of general practitioner (GP) density in the Paris metropolitan area: the density of GPs present (that is, practising) in the census block and of those registering new patients for office visits and, separately, for house calls.

Study Design: An exhaustive simulated patient survey enabled us to determine the number of GPs practising in the Paris metropolitan region accepting new patient registration for continuing care at their office and/or for house calls.

Methods: We measured at the level of a census block three types of GP densities: density of GPs present, density of GPs registering new patients at their office and density of GP registering new patients for house calls.

Simplified Method for Kinetic and Thermodynamic Screening of Cardiotonic Steroids through the K-Dependent Phosphatase Activity of Na/K-ATPase with Chromogenic pNPP Substrate.

The antitumor effect of cardiotonic steroids (CTS) has stimulated the search for new methods to evaluate both kinetic and thermodynamic aspects of their binding to Na/K-ATPase (IUBMB Enzyme Nomenclature). We propose a real-time assay based on a chromogenic substrate for phosphatase activity (pNPPase activity), using only two concentrations with an inhibitory progression curve, to obtain the association rate ( ), dissociation rate ( ), and equilibrium ( ) constants of CTS for the structure-kinetics relationship in drug screening. We show that changing conditions (from ATPase to pNPPase activity) resulted in an increase of of the cardenolides digitoxigenin, essentially due to a reduction of In contrast, the of the structurally related bufadienolide bufalin increased much less due to the reduction of its partially compensating the decrease of its When evaluating the kinetics of 15 natural and semisynthetic CTS, we observed that both and correlated with (Spearman test), suggesting that differences in potency depend on variations of both and A rhamnose in C3 of the steroidal nucleus enhanced the inhibitory potency by a reduction of rather than an increase of Raising the temperature did not alter the of digitoxin, generating a ΔH ( ) of -10.

Assessment of Prognostic Scores for Emergency Department Patients With Upper Gastrointestinal Bleeding.

Study Objective: Early prognostic stratification could optimize the management of patients with upper gastrointestinal bleeding and reduce unnecessary hospitalizations. The aim of this study was to assess and compare the performance of existing prognostic scores in predicting therapeutic intervention and death.

Methods: A systematic search of the literature identified existing prognostic scores.

Electrocatalytic dehydrogenative and defluorinative coupling between aldehyde-derived ,-dialkylhydrazones and fluoromalonates: synthesis of 2-pyrazolines.

An electrocatalytic synthesis of 2-pyrazolines dehydrogenative and defluorinative cross-coupling reactions between (hetero)arylaldehyde-derived ,-dialkylhydrazones and fluoromalonates is disclosed. Salient features of this work include (i) readily available starting materials, (ii) practical reaction conditions, and (ii) a formal oxidative (4 + 1)-cycloaddition triple C-H bond functionalization. Cyclic voltammetry analyses support the electrocatalytic formation of an α-fluoromalonyl radical.

Evaluation of use and identification of predictive factors for nonuse of peripheral venous catheters in the emergency department.

The placement of peripheral venous catheters (PVC) is a frequent procedure in the emergency department (ED), which exposes patients to complications (hematoma, fluid leakage, phlebitis, edema, infection), increases hemolysis of blood samples, is time-consuming and costly. The main aim of this study is to analyze the rate of PVC nonuse in the ED and to identify predictive factors of their nonuse. This prospective single-center observational study was conducted in the ED of the Saint-Antoine Hospital in Paris, France between February and March 2022.

Assessing the reaction to and efficacy of the Screener drug discovery and development board game as a pedagogical tool in postgraduate courses.

Screener, a board game supplemented with online resources, was introduced and distributed by the Brazilian Society of Pharmacology and Experimental Therapeutics to postgraduate programs as an instructional tool for the process of drug discovery and development (DDD). In this study, we provided a comprehensive analysis of five critical aspects for evaluating the quality of educational games, namely: 1) description of the intervention; 2) underlying pedagogical theory; 3) identification of local educational gaps; 4) impact on diverse stakeholders; and 5) elucidation of iterative quality enhancement processes. We also present qualitative and quantitative assessments of the effectiveness of this game in 11 postgraduate courses.

Two cases of extensively drug-resistant (XDR) infection combining ceftriaxone-resistance and high-level azithromycin resistance, France, November 2022 and May 2023.

We report two extensively drug-resistant (XDR) (NG) isolates combining high-level resistance to azithromycin and resistance to ceftriaxone, obtained in France from two heterosexual patients, one of whom returned from Cambodia. Whole genome sequencing identified MLST ST16406, the mosaic -60.001 which caused ceftriaxone resistance in the internationally spreading FC428 clone, and the A2059G mutation in the 23S rRNA gene.

[When a metastasis hides another].

Breast cancer is one of the leading causes of death in women. There are many different entities, both morphologically and immuno-histochemically or genomically. Intra-tumour heterogeneity can be defined in time (temporal heterogeneity) and in space (spatial heterogeneity) and is influenced by both internal and external factors, such as genetics, epigenetics, host response, possible treatments or the tumour microenvironment.

Improved Limits on Lepton-Flavor-Violating Decays of Light Pseudoscalars via Spin-Dependent μ→e Conversion in Nuclei.

Lepton-flavor-violating decays of light pseudoscalars, P=π^{0},η,η^{'}→μe, are stringently suppressed in the standard model up to tiny contributions from neutrino oscillations, so that their observation would be a clear indication for physics beyond the standard model. However, in effective field theory such decays proceed via axial-vector, pseudoscalar, or gluonic operators, which are, at the same time, probed in spin-dependent μ→e conversion in nuclei. We derive master formulas that connect both processes in a model-independent way in terms of Wilson coefficients and study the implications of current μ→e limits in titanium for the P→μe decays.

Inpatient Physical Therapy in Moderate to Severe Traumatic Brain Injury in in Older Adults: A Scoping Review.

Background: Around 500/100,000 Canadians experience a traumatic brain injury (TBI) resulting in long-term disabilities and premature death. Physiotherapy is known to positively impact the prognosis of young adults following a TBI.

Objective: This is a scoping review that aimed to identify research topics in physiotherapy interventions for seniors after a TBI, describe potential knowledge gaps, and uncover needs for future research.

L-proline transporter inhibitor (LQFM215) promotes neuroprotection in ischemic stroke.

Background: L-proline transporter (PROT/SLC6A7) is closely associated with glutamatergic neurotransmission, where L-proline modulates the NMDA receptor (NMDAR) function. NMDAR-mediated excitotoxicity is a primary cause of neuronal death following stroke, which is triggered by the uncontrolled release of glutamate during the ischemic process. After ischemic stroke, L-proline levels show a reduction in the plasma, but high circulating levels of this molecule indicate good functional recovery.

Propagation of an idealized infection in an airway tree, consequences of the inflammation on the oxygen transfer to blood.

A mathematical model of infection, inflammation and immune response in an idealized bronchial tree is developed. This work is based on a model from the literature that is extended to account for the propagation dynamics of an infection between the airways. The inflammation affects the size of the airways, the air flows distribution in the airway tree, and, consequently, the oxygen transfers to blood.

French consumer evaluation of eating quality of Angus x Salers beef: Effects of muscle cut, muscle slicing and ageing.

Based on the Meat Standards Australia (MSA) methodology, the objectives of this study were to evaluate the eating quality of grass-fed Angus x Salers beef by French consumers, across different muscle cuts (m. triceps brachii caput longum, m. longissimus dorsi et thoracis and m.

Accelerating the pace of value-based transformation for more resilient and sustainable healthcare.

Value-based healthcare (VBHC; delivering the best possible health outcomes for patients in a cost-efficient manner) has been a strategic priority among healthcare stakeholders for years. Pioneering providers embrace VBHC principles (such as organising care delivery around medical conditions, monitoring health outcomes and costs per patient group along the clinical pathway, and using those metrics to drive organisational improvements). Still, widespread adoption has been slow due to multiple factors, one of which is the sheer complexity of such a transformation.

Meta-Analysis of Human Cancer Single-Cell RNA-Seq Datasets Using the IMMUcan Database.

Unlabelled: The development of single-cell RNA sequencing (scRNA-seq) technologies has greatly contributed to deciphering the tumor microenvironment (TME). An enormous amount of independent scRNA-seq studies have been published representing a valuable resource that provides opportunities for meta-analysis studies. However, the massive amount of biological information, the marked heterogeneity and variability between studies, and the technical challenges in processing heterogeneous datasets create major bottlenecks for the full exploitation of scRNA-seq data.

Carcass Characteristics and Beef Quality of Young Grass-Fed Angus x Salers Bovines.

To characterize carcass and meat attributes, such as beef eating quality in specific farming conditions, 31 young grass-fed crossbred Angus x Salers cattle in two farming systems (a mono-cattle system versus a mixed system with beef cattle and sheep) were used in this study. Three muscle cuts (striploin-; bolar blade-; internal flank plate-) were used for consumer eating quality testing and striploin was used for panelist eating quality assessment, and objective measurements [Warner-Bratzler shear force (WBSF) and fatty acid (FA) and antioxidant contents]. Results indicated that the farming system had no impact on carcass characteristics or meat quality, but it tended to affect FA content, which is likely explained by between-system differences in animal maturity (assessed by ossification score).

Design, Synthesis and Pharmacological Evaluation of Novel Conformationally Restricted -arylpiperazine Derivatives Characterized as D/D Receptor Ligands, Candidates for the Treatment of Neurodegenerative Diseases.

Most neurodegenerative diseases are multifactorial, and the discovery of several molecular mechanisms related to their pathogenesis is constantly advancing. Dopamine and dopaminergic receptor subtypes are involved in the pathophysiology of several neurological disorders, such as schizophrenia, depression and drug addiction. For this reason, the dopaminergic system and dopamine receptor ligands play a key role in the treatment of such disorders.

Effect of S-Se Bioisosteric Exchange on Affinity and Intrinsic Efficacy of Novel -acylhydrazone Derivatives at the Adenosine A Receptor.

In this work, we evaluated the conformational effect promoted by the isosteric exchange of sulfur by selenium in the heteroaromatic ring of new -acylhydrazone (NAH) derivatives (-, , ), analogues of the cardioactive compounds LASSBio-294 () and LASSBio-785 (). NMR spectra analysis demonstrated a chemical shift variation of the iminic C of NAH S/Se-isosters, suggesting a stronger intramolecular chalcogen interaction for Se-derivatives. To investigate the pharmacological profile of these compounds at the adenosine A receptor (AR), we performed a previously validated functional binding assay.

SCREENER, an educational game for teaching the Drug Discovery and Development process.

Although the use of games as an educational strategy is an important current trend, there is practically no option available for training people on the Drug Discovery and Development (DDD) process. To fill this gap, we designed "SCREENER", a science game that is intended to be educational, but also challenging and interesting enough to ensure player engagement. Our main target audience is students of postgraduate programs in pharmacology, medicinal chemistry, pharmacy, and medicine.

On the scalar form factor beyond the elastic region.

Pion-kaon ( ) pairs occur frequently as final states in heavy-particle decays. A consistent treatment of scattering and production amplitudes over a wide energy range is therefore mandatory for multiple applications: in Standard Model tests; to describe crossed channels in the quest for exotic hadronic states; and for an improved spectroscopy of excited kaon resonances. In the elastic region, the phase shifts of scattering in a given partial wave are related to the phases of the respective form factors by Watson's theorem.