Inhibition of the interaction between fibronectin and dermatopontin by Clostridium perfringens fibronectin-binding proteins.

Fibronectin (Fn) is an approximately 450 kDa glycoprotein that consists of 12 type I, 2 type II, and 15-17 type III modules. Fibrillation of Fn is important for tissue reconstitution and wound healing. We previously reported that Clostridium perfringens produces several Fn-binding proteins (Fbps), two of which, FbpA and FbpB, bind to III -C (a fragment of Fn derived from the carboxyl-terminal two-thirds of the first-type III module).